DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer

Diagnostic Pathology

Table 2 The relationship between DLC-1, RhoA, ROCK2, moesin and clinicopathological variables in HCC tissues

Clinicopatholog-ical variables	DLC1 expression			RhoA expression			Rock2 expression			moesin expression
	H	L	p	H	L	p	H	L	p	H	L	p
Gender
Male	23	38	0.731	48	13	0.98	46	15	0.879	55	8	0.29
Female	8	11	0.731	15	4	0.98	14	5	0.879	15	4	0.29
Age (years)
< 45	9	14	0.958	17	6	0.502	17	6	0.887	19	4	0.548
≥ 45	22	35	0.958	46	11	0.502	43	14	0.887	50	7	0.548
Tumor number
Singel	20	30	0.767	40	10	0.724	39	11	0.424	43	7	0.933
Multiple	11	19	0.767	23	7	0.724	21	9	0.424	26	4	0.933
Maximal tumor size (cm)
< 5	19	30	0.995	38	11	0.742	37	13	0.789	43	6	0.623
≥ 5	12	19	0.995	25	6	0.742	23	7	0.789	26	5	0.623
Tumor differentiation
I-II	12	49	<0.001	36	15	0.018	33	18	<0.001	41	10	0.043
III-IV	19	10	<0.001	27	2	0.018	27	2	<0.001	28	1	0.043
HBV infection
No	7	11	0.989	14	4	0.909	13	5	<0.001	15	3	0.683
Yes	24	38	0.989	49	13	0.909	47	15	<0.001	54	8	0.683
TNM stage
I-II	11	43	<0.001	39	15	0.034	37	17	0.002	44	10	0.074
III	20	6	<0.001	24	2	0.034	23	3	0.002	25	1	0.074
Portal vein invasion and dissemination
Yes	8	38	<0.001	39	7	<0.001	40	6	0.004	43	3	0.029
No	23	11	<0.001	14	20	<0.001	20	14	0.004			0.029

ISSN: 1746-1596