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Table 1 Mean values of IHC scores for CDX2, p120ctn, c-Myc and Jagged1

From: Increasing diagnostic accuracy to grade dysplasia in Barrett’s esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1

 

CDX2

Membranous p120ctn

Cytoplasmic p120ctn

c-Myc

JAG-1

Quartile scoring method

 ND-BE

3.4

3.7

0.6

2.2

3.6

 LGD

3.3

4.0

0.7

2.2

3.5

 HGD

2.7

3.6

2.1

2.8

3.8

 EAC

2.7

2.8

3.0

2.7

3.9

 p-value

p ≤ 0.01

p ≤ 0.001

p < 0.0001

p = 0.17

p = 0.10

IRS scoring method

 ND-BE

7.0

8.0

0.6

2.8

4.3

 LGD

6.2

10.0

0.8

3.2

5.2

 HGD

4.2

6.2

2.4

5.2

5.3

 EAC

4.1

4.1

3.0

4.6

6.6

 p-value

p ≤ 0.01

p ≤ 0.001

p ≤ 0.001

p ≤ 0.05

p ≤ 0.001