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Table 1 Mean values of IHC scores for CDX2, p120ctn, c-Myc and Jagged1

From: Increasing diagnostic accuracy to grade dysplasia in Barrett’s esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1

  CDX2 Membranous p120ctn Cytoplasmic p120ctn c-Myc JAG-1
Quartile scoring method
 ND-BE 3.4 3.7 0.6 2.2 3.6
 LGD 3.3 4.0 0.7 2.2 3.5
 HGD 2.7 3.6 2.1 2.8 3.8
 EAC 2.7 2.8 3.0 2.7 3.9
 p-value p ≤ 0.01 p ≤ 0.001 p < 0.0001 p = 0.17 p = 0.10
IRS scoring method
 ND-BE 7.0 8.0 0.6 2.8 4.3
 LGD 6.2 10.0 0.8 3.2 5.2
 HGD 4.2 6.2 2.4 5.2 5.3
 EAC 4.1 4.1 3.0 4.6 6.6
 p-value p ≤ 0.01 p ≤ 0.001 p ≤ 0.001 p ≤ 0.05 p ≤ 0.001