Table 2 Summary of cutaneous squamous cell lesions with clear cell/signet-ring cell morphology

1

69/M

SRSCC

forehead

N/A

Kreyberg Stain

keratin

N/A

N/A

N/A

11

2

50/M

SRSCC

neck

PAS (septum between vacuoles)

Mucicarmine, PAS (vacuoles)

AE1/AE3, MAK 6 Ker, Ker 903, CAM 5.2, CEA (weak), EMA (weak), Ki-67

Leu M1, S-100, HMB-45, Actin, Vimentin, SMA

Not done

Rough ER cisternal dilatation

9

3

79/F

SCC

right cheek

No

colloical iron, PAS

cytokeratin

No

not done

no stained material

12

4

82/M

SCC

left temple

No

colloical iron, PAS

cytokeratin

No

Not done

no stained material

5

83/M

SCC

right ear

No

colloical iron, PAS

cytokeratin

No

Not done

no stained material

6

80/M

SCC

forehead

No

colloical iron, PAS

cytokeratin

No

Not done

no stained material

7

87/M

SCC

frontal scalp

No

colloical iron, PAS

cytokeratin

No

Not done

no stained material

8

76/M

SCC

forehead

No

colloical iron, PAS

cytokeratin

No

Not done

no stained material

9

84/F

SRSCC

upper lip

No

mucicarmine, PAS

keratin, P63, EMA

No

Not done

Not done

13

10

66/F

SCC

sole

AB, colloidal iron,

PAS

AE1/AE3, EMA, CK5/6

CK7, CK20, CEA, BerEP4, S100, Her2, ER, Ki-67

HPV 18

Not done

5

11

67/M

SCC

left lateral canthus

No

AB, mucicarmine, PAS

CK5/6, p63, EMA

CK7, Ck20, CEA

Not done

Not done

2

12

83/M

SRSCC

back of finger

No

Mucicarmine, PAS

No

CK20, CEA, vimentin, HMB45, Melan A, desmin

not done

not done

14

13

62/M

CCSCC

left side of face

No

PAS mucicarmine, AB

AE1/AE3

No

N/A

N/A

15

14

78/F

CC/SRSCC

right thigh

PAS

N/A

AE1/AE3, CK5/6, CK14, CK19, p63, FGFR2

CK7, CK8, CK18, CK20, P16, HER-2, p53, Ki-67

No HPV infection

Not done

present study