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Fig. 3 | Diagnostic Pathology

Fig. 3

From: In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity

Fig. 3

Expression levels of PTEN in normal colon mucosa, in various areas of primary tumor and in metastases. PTEN IHC was performed with antibodies from DAKO, CellSignaling and Neomarkers. Specimens were digitally imaged and H-scores were calculated based on a combination of staining intensity and frequency as described in methods. Data shown are mean PTEN (±95 % confidence interval) H-score values determined by the three antibodies and at the tumor regions indicated. Asterisk (*) marks significant difference (DAKO normal vs. border p = 0.005, all others p < 0.001 for all others) between the normal colon and all tumor regions detected by the DAKO and the CellSignaling antibody. There were no significant differences based on staining with the Neomarkers antibody

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Diagnostic Pathology

ISSN: 1746-1596

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