From: DEF6 expression in ovarian carcinoma correlates with poor patient survival
Variables | Total No. | Overall survival (OS) | Disease-free survival (DFS) | |||||
---|---|---|---|---|---|---|---|---|
HR | 95 % CI | P -value | HR | 95 % CI | P -value | |||
Age, years | 0.990 | 0.900 | ||||||
≦50 | 72 | 1.00a | 1.00a | |||||
>50 | 108 | 1.003 | 0.595–1.693 | 1.034 | 0.613–1.745 | |||
FIGO stage | 0.023* | 0.034* | ||||||
I | 86 | 1.00a | 1.00a | |||||
II | 23 | 1.141 | 0.518–2.511 | 1.119 | 0.509–2.460 | |||
III | 64 | 2.282 | 1.217–4.279 | 2.166 | 1.161–4.040 | |||
IV | 7 | 5.300 | 1.173–23.950 | 4.939 | 1.100–22.172 | |||
Histologic subtypes | 0.303 | 0.284 | ||||||
Serous carcinoma | 75 | 1.00a | 1.00a | |||||
Mucinous carcinoma | 36 | 0.529 | 0.247–1.135 | 0.531 | 0.247–1.138 | |||
Endometrioid carcinoma | 28 | 0.786 | 0.342–1.808 | 0.882 | 0.382–2.037 | |||
Clear cell carcinoma | 41 | 0.607 | 0.317–1.162 | 0.608 | 0.318–1.163 | |||
DEF6 | 0.013* | 0.009* | ||||||
Scores 0 and 1 | 62 | 1.00a | 1.00a | |||||
Scores 2 and 3 | 118 | 2.041 | 1.159–3.594 | 2.119 | 1.202–3.737 | |||
p16 | 0.026* | 0.031* | ||||||
Scores 0 and 1 | 97 | 1.00a | 1.00a | |||||
Scores 2 and 3 | 80 | 1.919 | 1.082–3.402 | 1.873 | 1.057–3.318 | |||
p53 | 0.181 | 0.205 | ||||||
Scores 1 and 2 | 81 | 1.00a | 1.00a | |||||
Scores 0 and 3 | 98 | 1.450 | 0.841–2.499 | 1.421 | 0.825–2.448 |