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Table 3 Univariate analyses showing HRs for patient OS and DFS conferred age, FIGO stage, histologic subtypes, DEF6, p53, p16 and ER expression (N = 180)

From: DEF6 expression in ovarian carcinoma correlates with poor patient survival

Variables

Total No.

Overall survival (OS)

Disease-free survival (DFS)

HR

95 % CI

P -value

HR

95 % CI

P -value

Age, years

  

0.990

  

0.900

50

 

72

1.00a

  

1.00a

  

 >50

 

108

1.003

0.595–1.693

 

1.034

0.613–1.745

 

FIGO stage

  

0.023*

  

0.034*

 I

 

86

1.00a

  

1.00a

  

 II

 

23

1.141

0.518–2.511

 

1.119

0.509–2.460

 

 III

 

64

2.282

1.217–4.279

 

2.166

1.161–4.040

 

 IV

 

7

5.300

1.173–23.950

 

4.939

1.100–22.172

 

Histologic subtypes

  

0.303

  

0.284

 Serous carcinoma

 

75

1.00a

  

1.00a

  

 Mucinous carcinoma

 

36

0.529

0.247–1.135

 

0.531

0.247–1.138

 

 Endometrioid carcinoma

 

28

0.786

0.342–1.808

 

0.882

0.382–2.037

 

 Clear cell carcinoma

 

41

0.607

0.317–1.162

 

0.608

0.318–1.163

 

DEF6

  

0.013*

  

0.009*

 Scores 0 and 1

 

62

1.00a

  

1.00a

  

 Scores 2 and 3

 

118

2.041

1.159–3.594

 

2.119

1.202–3.737

 

p16

  

0.026*

  

0.031*

 Scores 0 and 1

 

97

1.00a

  

1.00a

  

 Scores 2 and 3

 

80

1.919

1.082–3.402

 

1.873

1.057–3.318

 

p53

  

0.181

  

0.205

 Scores 1 and 2

 

81

1.00a

  

1.00a

  

 Scores 0 and 3

 

98

1.450

0.841–2.499

 

1.421

0.825–2.448

 
  1. aReference category for HR (Hazard Ratio) calculation with variable
  2. CI: Confidence Interval. (*Significant difference)