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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions

Fig. 2

Distinct p53 mutation patterns in SEIC and peritoneal carcinoma. (Upper sequences) p53 exon 5 sequences of the SEIC (left) and the peritoneal carcinoma (right). A somatic mutation from ATG to ACG (arrow) was detected in the SEIC, predicting the amino acid change p.Met169Thr. The peritoneal carcinoma had a wild-type sequence at this position. (Lower sequences) p53 exon 8 sequences of the SEIC (left) and the peritoneal carcinoma (right). A somatic mutation from CGT to CAT (arrow) was detected in the peritoneal carcinoma, predicting the amino acid change p.Arg273His. SEIC had a wild-type sequence at this position

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