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Table 3 Multivariate Cox regression analysis of the Ki-67 and the clinicopathological factors regarding distant metastasis-free survival and overall survival

From: Ki-67 as a controversial predictive and prognostic marker in breast cancer patients treated with neoadjuvant chemotherapy

Prognostic factor

Multivariate Cox regression regarding distant metastasis-free survival (n = 120)

Multivariate Cox regression analysis regarding overall survival (n = 120)

Multivariate Cox regression without Luminal-A cases regarding distant metastasis-free survival (n = 105)

Multivariate Cox regression without Luminal-A cases regarding overall survival (n = 105)

HR

95% CI

p-value

HR

95% CI

p-value

HR

95% CI

p-value

HR

95% CI

p-value

Age

0.964

0.653–1.487

0.919

1.532

0.950–2.470

0.080

0.933

0.565–1.540

0.787

1.477

0.928–2.350

0.100

pT

2.397

1.094–5.252

0.029

1.931

0.914–4.082

0.085

1.812

0.914–3.592

0.086

1.903

0.895–4.046

0.079

cT

0.771

0.356–1.671

0.510

1.173

0.505–2.726

0.711

0.831

0.341–2.024

0.685

1.176

0.507–2.724

0.706

IHC Subtype

1.676

0.436–6.439

0.452

2.230

1.231–4.043

0.008

3.263

0.369–22.823

0.287

2.135

1.202–3.785

0.009

Histological grade

1.280

0.415–3.945

0.667

1.641

0.559–4.815

0.367

1.381

0.394–4.836

0.614

1.278

0.453–3.605

0.643

pN

1.146

0.681–1.929

0.607

1.478

0.881–2.479

0.139

1.334

0.765–2.325

0.309

1.417

0.874–2.296

0.157

cN

1.641

0.724–3.717

0.235

1.502

0.694–3.253

0.302

1.980

0.837–4.682

0.120

1.485

0.685–3.219

0.317

Hormone receptor status

0.905

0.061–13.456

0.942

0.561

0.201–1.565

0.270

2.833

0.244–20.808

0.623

0.784

0.289–2.130

0.633

Pathological response

0.851

0.263–2.749

0.787

1.056

0.376–2.965

0.918

0.814

0.217–3.049

0.760

1.899

0.300–2.694

0.850

Ki-67 LI_D15%

1.628

0.288–9.209

0.581

2.022

0.373–10.962

0.414

2.105

0.288–15.843

0.353

1.568

0.287–8.570

0.604

Ki-67 LI_D20%

2.575

0.511–12.962

0.251

2.847

0.528–15.341

0.223

3.864

0.495–28.809

0.175

2.338

0.434–12.604

0.323

Ki-67 LI_D30%

1.217

0.353–4.201

0.756

5.286

1.189–23.488

0.029

1.361

0.352–5.255

0.655

4.850

1.089–18.379

0.038

  1. D15% = dichotomized at 15% threshold
  2. D20% = dichotomized at 20% threshold
  3. D30% = dichotomized at 30% threshold
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Diagnostic Pathology

ISSN: 1746-1596

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