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Table 3 Multivariate Cox regression analysis of the Ki-67 and the clinicopathological factors regarding distant metastasis-free survival and overall survival

From: Ki-67 as a controversial predictive and prognostic marker in breast cancer patients treated with neoadjuvant chemotherapy

Prognostic factor Multivariate Cox regression regarding distant metastasis-free survival (n = 120) Multivariate Cox regression analysis regarding overall survival (n = 120) Multivariate Cox regression without Luminal-A cases regarding distant metastasis-free survival (n = 105) Multivariate Cox regression without Luminal-A cases regarding overall survival (n = 105)
HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value
Age 0.964 0.653–1.487 0.919 1.532 0.950–2.470 0.080 0.933 0.565–1.540 0.787 1.477 0.928–2.350 0.100
pT 2.397 1.094–5.252 0.029 1.931 0.914–4.082 0.085 1.812 0.914–3.592 0.086 1.903 0.895–4.046 0.079
cT 0.771 0.356–1.671 0.510 1.173 0.505–2.726 0.711 0.831 0.341–2.024 0.685 1.176 0.507–2.724 0.706
IHC Subtype 1.676 0.436–6.439 0.452 2.230 1.231–4.043 0.008 3.263 0.369–22.823 0.287 2.135 1.202–3.785 0.009
Histological grade 1.280 0.415–3.945 0.667 1.641 0.559–4.815 0.367 1.381 0.394–4.836 0.614 1.278 0.453–3.605 0.643
pN 1.146 0.681–1.929 0.607 1.478 0.881–2.479 0.139 1.334 0.765–2.325 0.309 1.417 0.874–2.296 0.157
cN 1.641 0.724–3.717 0.235 1.502 0.694–3.253 0.302 1.980 0.837–4.682 0.120 1.485 0.685–3.219 0.317
Hormone receptor status 0.905 0.061–13.456 0.942 0.561 0.201–1.565 0.270 2.833 0.244–20.808 0.623 0.784 0.289–2.130 0.633
Pathological response 0.851 0.263–2.749 0.787 1.056 0.376–2.965 0.918 0.814 0.217–3.049 0.760 1.899 0.300–2.694 0.850
Ki-67 LI_D15% 1.628 0.288–9.209 0.581 2.022 0.373–10.962 0.414 2.105 0.288–15.843 0.353 1.568 0.287–8.570 0.604
Ki-67 LI_D20% 2.575 0.511–12.962 0.251 2.847 0.528–15.341 0.223 3.864 0.495–28.809 0.175 2.338 0.434–12.604 0.323
Ki-67 LI_D30% 1.217 0.353–4.201 0.756 5.286 1.189–23.488 0.029 1.361 0.352–5.255 0.655 4.850 1.089–18.379 0.038
  1. D15% = dichotomized at 15% threshold
  2. D20% = dichotomized at 20% threshold
  3. D30% = dichotomized at 30% threshold