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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

Fig. 1

Macrophages in resting state suffer microenvironmental effects coordinated by OSCC cells. Interleukin (IL)-1, IL-4, IL-6, IL-8 and IL-10 (not shown), and Gas-6 are produced by OSCC cells and promote macrophage phenotype switching to an M2 polarization state. In turn, TAMs augment the recruitment of chemotactic receptors to tumour sites, induce tumour proliferation, and favour angiogenesis and invasiveness [31, 32, 36, 40–43, 47, 48, 65, 66]

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Diagnostic Pathology

ISSN: 1746-1596

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