Fig. 2

A low-power view of tumor tissue by transurethral cystoscopy and biopsy (a), HE staining reveals that round and polygonal epithelioid-like cells with a sheet or nest-like distribution (b), A high-power view shows the obvious cytologic atypia and atypical mitoses of the tumor cells (c, arrows). Immunohistochemical staining shows tumor cells are negative for CK (d), scattered positive for P63 (e), while diffuse positive for CD21 (f)