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Table 3 Highly significantly enriched pathways for differentially expressed genes in T2D + CAD group

From: A comparison of gene expression profiles in patients with coronary artery disease, type 2 diabetes, and their coexisting conditions

KEGG ID KEGG term Count FDR Genes
hsa05144 Malaria 7 1.51E-04 IL1B,IL6,HBD,GYPC,IL8,HBA2,KLRB1
hsa03010 Ribosome 9 1.82E-04 RPS3A,UBA52,RSL24D1,RPL7,RPL39,RPL21,RPL34,RPS24,RPS12
hsa04620 Toll-like receptor signaling pathway 7 1.01E-02 IL1B,IL6,TBK1,CCL3,IL8,TLR5,CCL4
hsa05211 Renal cell carcinoma 6 1.18E-02 HIF1A,NRAS,RAP1A,PAK6,RAP1B,SLC2A1
hsa05020 Prion diseases 4 1.38E-02 IL1B,IL6,EGR1,PRKACB
hsa05143 African trypanosomiasis 4 1.38E-02 IL1B,IL6,HBD,HBA2
hsa04621 NOD-like receptor signaling pathway 5 1.54E-02 IL1B,IL6,CXCL1,BIRC3,IL8
hsa05323 Rheumatoid arthritis 6 1.59E-02 IL1B,IL6,CXCL1,ATP6V0E1,CCL3,IL8
hsa04062 Chemokine signaling pathway 9 1.64E-02 NRAS,RAP1A,CXCL1,RAP1B,CCL3,IL8,CCL4,JAK2,PRKACB
hsa04010 MAPK signaling pathway 10 1.94E-02 IL1B,NRAS,RAP1A,RASA2,PPM1A,LAMTOR3,RAP1B,NR4A1,DUSP2,PRKACB
hsa00860 Porphyrin and chlorophyll metabolism 4 1.98E-02 FECH,BLVRB,HMBS,ALAS2
hsa00100 Steroid biosynthesis 3 2.06E-02 SOAT1,CYP2R1,C5orf4
hsa04720 Long-term potentiation 5 2.19E-02 NRAS,RAP1A,RAP1B,RAPGEF3,PRKACB
hsa04120 Ubiquitin mediated proteolysis 7 2.29E-02 CDC34,CDC27,BIRC3,UBE2W,SKP1,UBE2E3,CUL3
hsa05200 Pathways in cancer 11 2.52E-02 IL6,BCL2L1,HIF1A,NRAS,PTEN,BIRC3,IL8,ITGB1,DAPK1,SLC2A1,PTGS2