Table 3 Highly significantly enriched pathways for differentially expressed genes in T2D + CAD group
KEGG ID | KEGG term | Count | FDR | Genes |
|---|---|---|---|---|
hsa05144 | Malaria | 7 | 1.51E-04 | IL1B,IL6,HBD,GYPC,IL8,HBA2,KLRB1 |
hsa03010 | Ribosome | 9 | 1.82E-04 | RPS3A,UBA52,RSL24D1,RPL7,RPL39,RPL21,RPL34,RPS24,RPS12 |
hsa04620 | Toll-like receptor signaling pathway | 7 | 1.01E-02 | IL1B,IL6,TBK1,CCL3,IL8,TLR5,CCL4 |
hsa05211 | Renal cell carcinoma | 6 | 1.18E-02 | HIF1A,NRAS,RAP1A,PAK6,RAP1B,SLC2A1 |
hsa05020 | Prion diseases | 4 | 1.38E-02 | IL1B,IL6,EGR1,PRKACB |
hsa05143 | African trypanosomiasis | 4 | 1.38E-02 | IL1B,IL6,HBD,HBA2 |
hsa04621 | NOD-like receptor signaling pathway | 5 | 1.54E-02 | IL1B,IL6,CXCL1,BIRC3,IL8 |
hsa05323 | Rheumatoid arthritis | 6 | 1.59E-02 | IL1B,IL6,CXCL1,ATP6V0E1,CCL3,IL8 |
hsa04062 | Chemokine signaling pathway | 9 | 1.64E-02 | NRAS,RAP1A,CXCL1,RAP1B,CCL3,IL8,CCL4,JAK2,PRKACB |
hsa04010 | MAPK signaling pathway | 10 | 1.94E-02 | IL1B,NRAS,RAP1A,RASA2,PPM1A,LAMTOR3,RAP1B,NR4A1,DUSP2,PRKACB |
hsa00860 | Porphyrin and chlorophyll metabolism | 4 | 1.98E-02 | FECH,BLVRB,HMBS,ALAS2 |
hsa00100 | Steroid biosynthesis | 3 | 2.06E-02 | SOAT1,CYP2R1,C5orf4 |
hsa04720 | Long-term potentiation | 5 | 2.19E-02 | NRAS,RAP1A,RAP1B,RAPGEF3,PRKACB |
hsa04120 | Ubiquitin mediated proteolysis | 7 | 2.29E-02 | CDC34,CDC27,BIRC3,UBE2W,SKP1,UBE2E3,CUL3 |
hsa05200 | Pathways in cancer | 11 | 2.52E-02 | IL6,BCL2L1,HIF1A,NRAS,PTEN,BIRC3,IL8,ITGB1,DAPK1,SLC2A1,PTGS2 |