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Table 3 Multivariate Cox regression analysis for the survival of gastric carcinoma patients

From: Individual and co-expression patterns of nerve growth factor and heme oxygenase-1 predict shorter survival of gastric carcinoma patients

Characteristics OS   RFS  
  HR (95% CI) p HR (95% CI) p
Model 1a
 Tumor stage, III & IV (vs I & II) 4.226 (2.406-7.422) <0.001 4.134 (2.414-7.082) <0.001
 Venous invasion, presence (vs absence) 2.129 (1.249-3.629) 0.006 1.959 (1.156-3.317) 0.012
 HO1, positive (vs negative) 2.382 (1.464-3.876) <0.001 2.099 (1.312-3.356) 0.002
Model 2b
 Tumor stage, III & IV (vs I and II) 4.373 (2.482-7.706) <0.001 4.203 (2.449-7.214) <0.001
 Venous invasion, presence (vs absence) 2.147 (1.252-3.681) 0.005 2.104 (1.231-3.597) 0.007
 NGF/HO1 expression, −/− 1 0.002 1 0.003
  −/+ or +/− 2.222 (1.230-4.014) 0.008 1.888 (1.074-3.320) 0.038
  +/++ 3.040 (1.628-5.677) <0.001 2.818 (1.552-5.116) 0.001
  1. Abbreviations: HR hazard ratio
  2. aVariables considered in the Model 1 were the pretreatment serum level of CEA and CA19-9, histologic grade, tumor stage, tumor invasion (EGC versus AGC), lymph node metastasis, venous invasion, and expression of NGF and HO1
  3. bVariables considered in the Model 2 were the pretreatment serum level of CEA and CA19-9, histologic grade, tumor stage, tumor invasion, lymph node metastasis, venous invasion, and co-expression pattern of NGF and HO1