Individual and co-expression patterns of nerve growth factor and heme oxygenase-1 predict shorter survival of gastric carcinoma patients

Table 3 Multivariate Cox regression analysis for the survival of gastric carcinoma patients

Characteristics	OS		RFS
	HR (95% CI)	p	HR (95% CI)	p
Model 1^a
Tumor stage, III & IV (vs I & II)	4.226 (2.406-7.422)	<0.001	4.134 (2.414-7.082)	<0.001
Venous invasion, presence (vs absence)	2.129 (1.249-3.629)	0.006	1.959 (1.156-3.317)	0.012
HO1, positive (vs negative)	2.382 (1.464-3.876)	<0.001	2.099 (1.312-3.356)	0.002
Model 2^b
Tumor stage, III & IV (vs I and II)	4.373 (2.482-7.706)	<0.001	4.203 (2.449-7.214)	<0.001
Venous invasion, presence (vs absence)	2.147 (1.252-3.681)	0.005	2.104 (1.231-3.597)	0.007
NGF/HO1 expression, −/−	1	0.002	1	0.003
−/+ or +/−	2.222 (1.230-4.014)	0.008	1.888 (1.074-3.320)	0.038
+/+⁺	3.040 (1.628-5.677)	<0.001	2.818 (1.552-5.116)	0.001

Abbreviations: HR hazard ratio
^aVariables considered in the Model 1 were the pretreatment serum level of CEA and CA19-9, histologic grade, tumor stage, tumor invasion (EGC versus AGC), lymph node metastasis, venous invasion, and expression of NGF and HO1
^bVariables considered in the Model 2 were the pretreatment serum level of CEA and CA19-9, histologic grade, tumor stage, tumor invasion, lymph node metastasis, venous invasion, and co-expression pattern of NGF and HO1

ISSN: 1746-1596