Computer-assisted stereology and automated image analysis for quantification of tumor infiltrating lymphocytes in colon cancer

Table 2 Correlation between central and invasive area for density estimates

	Spearman correlation All sections (n = 129)	Spearman correlation Deepest section (n = 43)	Spearman correlation Random section A (n = 43)	Spearman correlation Random section B (n = 43)
CD3-Central	0.9457	0.9623	0.9328	0.9080
CD8-Central	0.9638	0.9609	0.9745	0.9431
CD3-Invasive	0.9496	0.9678	0.9420	0.9644
CD8-Invasive	0.9552	0.9782	0.9367	0.9381

Correlation between numerical densities of CD3+ and CD8+ tumor infiltrating lymphocytes per mm² in central and invasive tumor areas, respectively, estimated by either stereology or image analysis for all tumor sections and for individual tumor sections. Spearman’s correlation, p < 0.0001

ISSN: 1746-1596