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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Physical basis of the ‘magnification rule’ for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer

Fig. 1

Her2-IHC scoring categories reflect DAB-precipitate widths. Table: Microscope objectives have a fixed resolution that depends on the numerical aperture (Range: Values of common objectives). DAB-precipitates in HER2-IHC differ in width according to the intensity score. a histogram: Summary of 1200 DAB-precipitate-width measurements in μm. b bar chart: Mean DAB-width (bars) ±SD (antennae); resolution of standard microscope objectives (dashed lines). c images: Representative HER2-IHC stainings of invasive ductal breast carcinomas according to intensity score

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Diagnostic Pathology

ISSN: 1746-1596

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