Table 1 Summary of relationship between high-grade serous carcinogenesis and p53 immunophenotype

Diffuse positive (also called overexpression)

p53 signature [14]

HGSC with p53 overexpression, which may reflect GOF p53

Diffuse negative (also called as null, complete absence)

γ-H2AX responsive foci, see Discussion section

HGSC without p53 expression, which may reflect LOF p53

Cytoplasmic staining

Not proposed, but probably misinterpreted as a p53 signature

HGSC with p53 cytoplasmic expression, which is a rare immunophenotype with uncertain clinicopathological significance

Wild-type

SCOUT [17]

HGSC NOS, which shows any p53 immunophenotype