Table 4 Intra-block concordance (OPA; PPA; NPA) in PD-L1 classification of NSCLC samples at various applied cut-offs
Applied cut-off | OPA % (lower 95% CI) | PPA % (lower 95% CI) | NPA % (lower 95% CI) |
|---|---|---|---|
TC PD-L1 staining | |||
  ≥ 50% | 97.0 (94.2) | 92.2 (84.3) | 99.3 (96.6) |
  ≥ 25% | 98.5 (96.2) | 96.7 (91.6) | 100.0 (97.3) |
  ≥ 10% | 96.5 (93.5) | 95.3 (90.4) | 97.8 (93.4) |
  ≥ 1% | 91.0 (86.9) | 96.2 (92.1) | 81.4 (72.1) |
IC PD-L1 staining | |||
  ≥ 50% | 95.5 (92.3) | 14.3 (0.7) | 98.4 (96.0) |
  ≥ 25% | 86.5 (81.9) | 17.9 (7.3) | 97.7 (94.8) |
  ≥ 10% | 78.5 (73.2) | 78.1 (71.9) | 79.6 (67.8) |
  ≥ 1% | 80.5 (75.3) | 81.6 (75.6) | 77.1 (64.9) |