Predictive value of tumor-infiltrating lymphocytes to pathological complete response in neoadjuvant treated triple-negative breast cancers

Table 1 Correlations between TILs and clinicopathologic characteristics in TNBCs

Characteristics	No. of patients (%)	P-value of sTILs	P-value of iTILs
Age (years)
< 50	80 (48.2)	0.87^a	0.79^a
≥ 50	86 (51.8)
Tumor size (cm)
≤ 2	22 (13.2)	0.88^b	0.16^b
2–5	115 (69.3)
> 5	29 (17.5)
Lymph node status
Negative	53 (31.9)	0.78^a	0.23^a
Positive	113 (68.1)
Histological type
IDC	164 (98.8)	0.58^a	0.33^a
Special type	2 (1.2)
Histological grade
2	31 (18.7)	0.004^a+	0.03^a+
3	135 (81.3)
LVI
Negative	130 (78.3)	0.17^a	0.03^a+
Positive	36 (21.7)
Miller-Payne grade
1	17 (10.2)	0.001^b+	0.06^b
2	26 (15.7)
3	32 (19.3)
4	24 (14.4)
5	67 (40.4)
NAC
Anthracycline + paclitaxel	136 (81.9)	0.98^a	0.99^a
Paclitaxel + platinum	30 (18.1)

Abbreviations: TNBCs triple-negative breast cancers, sTILs stromal tumor-infiltrating lymphocytes, iTILs intratumoral tumor-infiltrating lymphocytes, IDC invasive ductal carcinoma of no special type, LVI lymphovascular invasion, NAC neoadjuvant chemotherapy
^aMann-Whitney test
^bKruskal-Wallis test
⁺The p value is significant

ISSN: 1746-1596