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Table 5 Comparisons between different thresholds of sTILs and iTILs

From: Predictive value of tumor-infiltrating lymphocytes to pathological complete response in neoadjuvant treated triple-negative breast cancers

Threshold (%) No. of patients (%) Sensitivity (%) Specificity (%) PPV (%)a NPV (%) Accuracy (%) Youden’s Index
STILs
 20 41.6 56.7 68.7 55.1 70.1 63.9 0.254
 50 4.2 9.0 99.0 85.7 61.6 62.7 0.08
 60 1.8 4.5 100.0 100.0 60.7 61.4 0.045
ITILs
 10 42.8 56.7 66.7 53.5 69.5 62.7 0.234
 20 4.2 8.9 98.9 85.7 61.6 62.7 0.078
 30 1.2 2.9 100.0 100.0 60.4 60.8 0.029
  1. Abbreviations: sTILs stromal tumor-infiltrating lymphocytes, iTILs intratumoral tumor-infiltrating lymphocytes, PPV positive predictive value, NPV negative predictive value, Youden’s Index = sensitivity + specificity - 1
  2. aPPV = pCR rate