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Table 5 Comparisons between different thresholds of sTILs and iTILs

From: Predictive value of tumor-infiltrating lymphocytes to pathological complete response in neoadjuvant treated triple-negative breast cancers

Threshold (%)

No. of patients (%)

Sensitivity (%)

Specificity (%)

PPV (%)a

NPV (%)

Accuracy (%)

Youden’s Index

STILs

 20

41.6

56.7

68.7

55.1

70.1

63.9

0.254

 50

4.2

9.0

99.0

85.7

61.6

62.7

0.08

 60

1.8

4.5

100.0

100.0

60.7

61.4

0.045

ITILs

 10

42.8

56.7

66.7

53.5

69.5

62.7

0.234

 20

4.2

8.9

98.9

85.7

61.6

62.7

0.078

 30

1.2

2.9

100.0

100.0

60.4

60.8

0.029

  1. Abbreviations: sTILs stromal tumor-infiltrating lymphocytes, iTILs intratumoral tumor-infiltrating lymphocytes, PPV positive predictive value, NPV negative predictive value, Youden’s Index = sensitivity + specificity - 1
  2. aPPV = pCR rate
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Diagnostic Pathology

ISSN: 1746-1596

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