Fig. 3

Deleterious mutation in CDH1 found in the case studied. a Lollipop representation of deleterious mutation c.866delC in CDH1. E-cadherin motifs are represented in different colours. b IGV-browser view of mutation c.del866C through massive sequencing data from the case studied. Mutation is represented in both DNA strands (5′- > 3′, red, and 3′- > 5′, blue) in a high frequency of reads, supporting a homozygous status (through LOH) within tumour cells