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Table 1 Patient characteristics

From: PD1hi cells associate with clusters of proliferating B-cells in marginal zone lymphoma

Diagnosis Histology Age Stage LDH TTFT Alive OS Treatment
Extranodal Periorbital Diffuse 62 I 282 1 0 62 ISRT
Extranodal Periorbital Foliicular architecture with colonisation of follicles 59 I 257 NA 0 62 W&W
Nodal Diffuse 67 IV 329 1 0 70 Rituximab+CHOP
Nodal Diffuse 67 IV 424 1 0 49 Rituximab+FC
Extranodal Periorbital Residual germinal centres 48 IV 237 3 0 30 Rituximab+CVP + Rituximab maintenace
Nodal Diffuse 61 III 227 5 0 36 Rituximab+CHOP
Nodal Diffuse 73 I 248 NA 0 32 W&W
Nodal Diffuse 73 IV 206 3 0 67 ISRT
Splenic Diffuse 68 I ND NA 0 75 Splenectomy
Splenic Diffuse 61 IV ND 2 0 132 Splenic RT; CVP; Radiotherapy
Splenic Diffuse 72 IV 290 2 1 1 Chlorambucil
Nodal Diffuse 72 IV 277 1 1 1 Rituximab+CVP
Nodal Diffuse 55 IV 234 9 0 62 Obinutuzumab+CVP + Obinutuzumab maintenance
Extranodal Diffuse Diffuse 74 I ND NA 0 31 Lung lobectomy
Extranodal Diffuse Diffuse 63 I 202 NA 0 25 W&W
  1. The type of MZL is indicated (extranodal, nodal and splenic) and the site of extranodal disease together with the histological appearance (diffuse in 13/15 cases, with one case showing residual germinal centres and another case showing follicles with colonisation by lymphoma. Age (years), clinical stage (I to IV) and lactate dehydrogenase (LDH) are also shown. For LDH the upper limit of normal = 255 IU/L. ND not determined. Time to first treatment (TTFT) and overall survival (OS) in months is shown and whether the patients are alive (0) or dead (1). Three patients were managed by watch and wait (W&W) while the others received various treatments: involved site radiotherapy (ISRT), rituximab with cyclophosphamide, adriamycin, vincristine and prednisolone (CHOP), rituximab with cyclophosphamide, vincristine and prednisolone (CVP), obinutuzumab with CVP or rituximab with fludarabine and cyclophosphamide (FCR). Single agent chlorambucil, splenectomy or splenic radiotherapy were used as indicated