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Table 1 Patient characteristics

From: PD1hi cells associate with clusters of proliferating B-cells in marginal zone lymphoma

Diagnosis

Histology

Age

Stage

LDH

TTFT

Alive

OS

Treatment

Extranodal

Periorbital

Diffuse

62

I

282

1

0

62

ISRT

Extranodal

Periorbital

Foliicular architecture with colonisation of follicles

59

I

257

NA

0

62

W&W

Nodal

Diffuse

67

IV

329

1

0

70

Rituximab+CHOP

Nodal

Diffuse

67

IV

424

1

0

49

Rituximab+FC

Extranodal

Periorbital

Residual germinal centres

48

IV

237

3

0

30

Rituximab+CVP + Rituximab maintenace

Nodal

Diffuse

61

III

227

5

0

36

Rituximab+CHOP

Nodal

Diffuse

73

I

248

NA

0

32

W&W

Nodal

Diffuse

73

IV

206

3

0

67

ISRT

Splenic

Diffuse

68

I

ND

NA

0

75

Splenectomy

Splenic

Diffuse

61

IV

ND

2

0

132

Splenic RT; CVP; Radiotherapy

Splenic

Diffuse

72

IV

290

2

1

1

Chlorambucil

Nodal

Diffuse

72

IV

277

1

1

1

Rituximab+CVP

Nodal

Diffuse

55

IV

234

9

0

62

Obinutuzumab+CVP + Obinutuzumab maintenance

Extranodal

Diffuse

Diffuse

74

I

ND

NA

0

31

Lung lobectomy

Extranodal

Diffuse

Diffuse

63

I

202

NA

0

25

W&W

  1. The type of MZL is indicated (extranodal, nodal and splenic) and the site of extranodal disease together with the histological appearance (diffuse in 13/15 cases, with one case showing residual germinal centres and another case showing follicles with colonisation by lymphoma. Age (years), clinical stage (I to IV) and lactate dehydrogenase (LDH) are also shown. For LDH the upper limit of normal = 255 IU/L. ND not determined. Time to first treatment (TTFT) and overall survival (OS) in months is shown and whether the patients are alive (0) or dead (1). Three patients were managed by watch and wait (W&W) while the others received various treatments: involved site radiotherapy (ISRT), rituximab with cyclophosphamide, adriamycin, vincristine and prednisolone (CHOP), rituximab with cyclophosphamide, vincristine and prednisolone (CVP), obinutuzumab with CVP or rituximab with fludarabine and cyclophosphamide (FCR). Single agent chlorambucil, splenectomy or splenic radiotherapy were used as indicated