Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients

Diagnostic Pathology

Table 1 Correlations between HSF1 expression and the clinicopathologic variables of 117 GC patients

Characteristic	N	HSF1 Expression		Χ² Value	P value
Characteristic	N	Low(N = 53)	High(N = 64)
Gender
Male	73	35	38	0.548	0.459
Female	44	18	26	0.548	0.459
Age		56.87 ± 11.03	54.34 ± 13.821
<60 y	72	32	40	0.055	0.814
≥ 60 y	45	21	24	0.055	0.814
Tumor Location
Proximal	34	15	19	3.35	0.341
Middle	33	12	21
Distal	41	23	18
More than 2	6	2	4
Tumor size
<5 cm	67	39	28	10.545	0.001
≥ 5 cm	50	14	36	10.545	0.001
Histologic type
Adenocarcinoma	98	43	55	0.492	0.483
others	19	10	9	0.492	0.483
Bornmann classification
1	6	3	3	14.657	0.002
2	24	17	7
3	73	32	41
4	14	1	13
Differentiation
Well	25	14	11	1.469	0.225
Moderate/Poorly	92	39	53	1.469	0.225
Depth of invasion
1	8	7	1	10.512	0.015
2	4	3	1
3	84	38	47
4	20	5	15
Lymph node metastasis
0	33	26	7	24.989	<0.001
1	18	9	9
2	25	9	16
3	41	9	32
Distance metastasis
0	94	48	46	6.413	0.011
1	23	5	18	6.413	0.011
Tumor-node-metastasis stage
1	8	7	1	24.478	<0.001
2	37	26	11
3	49	15	34
4	23	5	18
CEA level (μg/L)
<5	104	48	56	0.139	0.709
≥ 5	10	4	6	0.139	0.709

ISSN: 1746-1596