Fig. 3
From: KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma
Recurrent low grade follicular lymphoma. A needle core biopsy reveals an abnormal infiltrate of small lymphocytes that are predominantly CD20+ B cells with coexpression of CD10, BCL6 and BCL2, consistent with low grade follicular lymphoma (a H&E, 200X, b CD20 IHC, 200X; c CD10, 200X, d BCL2 IHC, 200X). Dual color dual fusion FISH analysis confirms the presence of IgH/BCL2 fusion signals resulting from t(14;18) in 62% of cells analyzed (Inset)