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Table 3 Evaluations of immune protective response mediated by bacterial OMVs against infection in mice model

From: Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based

Parent bacteria Model establishment OMVs administration Adjuvant used Efficiency Immune response References
E. coli porcine pleuropneumonia subcutaneous aluminum 87.5% survival for APP serotype 7 Serum IgG Th1 and Th2 cytokines secretion 93
62.5% survival for APP serotype 1
S. Enteritidis foodborne infections of S. Enteritidis intranasal or intraperitoneal none 83.3% survival intranasally Serum IgG and secretory IgA 87
91% survival intraperitoneally
Salmonella enterica Oral infection Intranasally or intraperitoneally none 100% survival by Intraperitoneal immunization Serum IgG and mucosal IgA 94
80% survival by intranasal immunization
Neisseria meningitis Infection subcutaneous aluminum hydroxide 100% survival Serum IgG 95
Neisseria meningitidis Healthy neonatal mice intranasal and subcutaneous DODAB-BF and aluminum hydroxide Not mentioned IgG, Intranasal immunization, Th1 and Th2 response, 96
Th1 profile for subcutaneous immunization
P. gingivalis Infection intranasal Poly (I:C) Not mentioned Serum IgG (including IgG1 and IgG2a) salivary S-IgA 84
K. pneumoniae Sepsis intraperitoneal none 80% survival with 0.5 μg OMVs and 100% survival with 1 μg OMVs Serum IgG and the secretion of key cytokines of Th1 cells (IFN-γ) 62
B. pseudomallei Septicemic infection subcutaneous none 100% survival compared with40% survival in naive mice serum IgG (IgG1, IgG2a, and IgG3) and IgM 97
Bordetella pertussis Infection intraperitoneal none Not mentioned serum IgG, Th1 and Th17 response (the classic whole cell vaccine) 98
Th1/Th17 and Th2 mixed response (acellular vaccines)
V. cholerae Infection Oral immunization none > 80% protection serum IgG, IgA, IgM, mucosal sIgA, Th2 and Th17 cell response 99
Shigella boydii Infection Oral immunization none 100% protection mucosal IgG and IgA, Th1 cell response 54
B. abortus Infection subcutaneous Freund’s complete and incomplete adjuvant Not mentioned Serum IgG, cellular immune response 100
  1. Abbreviations: E.coli, Escherichia coli; APP, Actinobacillus pleuropneumoniae; S. Enteritidis, Salmonella Enteritidis; Th, T helper;P. gingivalis, Porphyromonas gingivalis;Ig, immunoglobulin; K. pneumoniae, Klebsiella pneumoniae;B. pseudomallei, Burkholderia pseudomallei; V. cholerae, Vibrio cholerae; B. abortus, Brucella abortus; Infection means mice challenged with the same bacteria if not specific statement