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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary

Fig. 2

Photomicrographs of pagetoid urothelial intraepithelial neoplasia extending to the vagina. a–f Punch biopsies from the vulva and anterior vaginal wall. a Large cells proliferating within the basal and parabasal layers of the vulvar squamous epithelium (hematoxylin and eosin [HE] stain, × 10). b Paget-like cells with larger nuclei and paler cytoplasm than the adjacent keratinocytes about clefts, an apparent artifact that is a common finding in pagetoid urothelial intraepithelial neoplasia (HE, × 400). c Similar cells of high nuclear grade identified in the mostly denuded vagina (HE, × 400). d Focal positivity for uroplakin III (immunohistochemical [IHC] stain, × 400). e Positivity for thrombomodulin (IHC, × 400). f Positivity for uroplakin II (IHC, × 400)

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Diagnostic Pathology

ISSN: 1746-1596

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