Fig. 3

Assessment for whole-arm 1p and 19q loss. Examples of single nucleotide polymorphism chromosomal arrays (SNP microarrays) for (a) IDH-mutant oligodendroglioma and (b) IDH-wildtype glioblastoma. Red arrows mark a neutral copy number, and blue arrows accompanied by red shading indicate areas of copy number loss. Note that in oligodendroglioma, the entire 1p and 19q arms show copy number loss. In contrast, for the glioblastoma, there is only focal loss of distal 1p, and a focal interstitial loss on 19q, with these areas encompassing the region that corresponds to FISH probes for 1p (orange shading) and 19q (green shading). The probe annealing regions are not to scale