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Table 4 Correlations between clinical data and pathologic classifications by the updated Oxford classification or the International Study of Kidney Disease in Children classification

From: Updated Oxford classification and the international study of kidney disease in children classification: application in predicting outcome of Henoch-Schönlein purpura nephritis

 

MAP, mmHg

P value

Proteinuria, g/24 h

P value

eGFR, ml/min/1.73m2

P value

Scr, μmol/L

P value

International Study of Kidney Disease in Children classification

ISKDC-G0

93.8 ± 10.7

 

0.75 (0.40, 1.75)

 

123.8 (96.0, 145.4)

 

60.0 (50.5, 75.0)

 

ISKDC-G1

95.9 ± 10.6

 

1.50 (0.75, 3.00) a

 

111.4 (81.4, 134.6) a

 

68.0 (55.0, 91.5) a

 

ISKDC-G2

95.0 ± 10.5

 

3.60 (2.00, 5.50)ab

 

30.7 (24.5, 138.6)ab

 

150.0 (56.0, 244.5)ab

 

Updated Oxford classification

Messangial proliferation

 M0

95.1 ± 10.4

0.303

1.23 (0.60, 3.00)

0.859

116.2 (87.6, 139.6)

0.429

65.0 (53.0, 81.3)

0.098

 M1

94.3 ± 12.4

1.34 (0.73, 3.01)

107.3 (85.5, 134.7)

72.0 (56.0, 92.0)

Endocapillary proliferation

 E0

94.5 ± 10.3

0.160

1.00 (0.46, 2.15)

< 0.001

118.6 (89.7, 136.3)

0.798

65.0 (54.0, 84.0)

0.946

 E1

96.2 ± 11.4

2.02 (1.00, 3.44)

110.4 (80.5, 145.3)

66.0 (52.0, 84.3)

Segmental sclerosis

 S0

91.5 ± 10.2

0.003

1.06 (0.52, 3.00)

0.423

130.4 (109.3, 144.9)

< 0.001

60.3 (51.0, 75.0)

< 0.001

 S1

96.8 ± 10.8

1.50 (0.70, 3.00)

99.0 (75.2, 125.1)

68.5 (59.3, 94.0)

Tubular atrophy/ interstitial fibrosis

 T0

94.9 ± 10.7

0.148

1.30 (0.64, 3.00)

0.273

118.9 (89.8, 139.4)

0.001

65.0 (54.0, 81.0)

0.001

 T1/T2

99.4 ± 7.1

2.72 (1.00, 3.43)

45.3 (18.4, 76.7)

138.5 (106.8, 276.0)

Crescents

 C0

93.6 ± 10.7

 

0.75 (0.42, 1.97)

 

124.2 (96. 5, 145.6)

 

59.1 (50.7, 74.0)

 

 C1

95.9 ± 11.0

 

1.50 (0.75, 3.05)c

 

114.8 (81.9, 134.8)c

 

70.2 (54.0, 89.0)c

 

 C2

95.1 ± 8.8

 

2.49 (1.33, 4.65)cd

 

95.9 (41.9, 131.9)c

 

68.6 (57.0, 150.5)c

 
  1. MAP, mean arterial pressure; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; ISKDC, International Study of Kidney Disease in Children. a P < 0.05 compared with ISKDC-G0, b P < 0.05 compared with ISKDC-G1; c P < 0.05compared with C0, d P < 0.05 compared with C1
  2. Results of MAP were provided in mean ± standard deviation while results of Scr, eGFR, proteinuria were provided in median and (interquartile range)