Fig. 2

Clear cell adenocarcinoma. Low magnification (a) and high magnification of the clear cell (b) and conventional components (c) with HE staining. The boundary (d) between the clear cell and conventional components at high magnification with HE staining. The clear cells are negative for PAS (e) and alcian blue staining (f), whereas both components of the tumor are positive for CDX2 (g). The localization of CEA (h) expression is diffusely cytoplasmic for the clear cell component and luminal cell apical for the conventional component. CD10 (i) and adipophilin (j) expression is confined to the clear component and Ki67 labeling (k) is higher in the clear cell component. g-k represent immunohistochemistry. Immunoelectron microscopy analysis (l) at low (left) and high magnification (right) reveals multiple cytoplasmic lipid-like vacuoles in clear cells that are negative for adipophilin