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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Rare cases of primary central nervous system anaplastic variant of diffuse large B-cell lymphoma

Fig. 1

Representative hematoxylin and eosin (H&E) and immunostaining analysis of primary CNS A-DLBCL. (a-c) All three cases showed scattered binucleated and multinucleated, bizarre Reed–Sternberg-like tumor cells (black arrow) in the background of ordinary DLBCL (a: patient 1, b: patient 2, c: patient 3). (d-f) A high power view of the anaplastic tumor cells of each case (d: patient 1, e: patient 2, f: patient 3). Tumor cells of patient 3 showed a diffuse strong positivity for BCL2 (g), MYC (h) and p53 (i). Patient 2 showed positive staining for the NF-κB subunits RELA (j), RELB (k) and c-Rel (l) in both cytoplasm and nucleus. A positive control of each immunostaining for anaplastic DLBCL tissues inset at the upper right corner

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