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Table 1 Morphologic, Immunophenotypic, and Molecular Genetic Characteristics of 3 Patients With Primary CNS A-DLBCL

From: Rare cases of primary central nervous system anaplastic variant of diffuse large B-cell lymphoma

  Cell of Origin Immunohistochemistry FISH Mutation Statuses
Patient Hans Choi CD5 CD30 Ki-67 BCL2 MYC P53 RELA RELB c-Rel MYC BCL2 BCL6 TP53 MYD88 CD79B CARD11 EZH2
(exon 5–10) (exon 5) (exon 5) (exon 5–9) (exon 16)
1 GCB GCB + 90% + + All negative + + + extracopy extracopy extracopy WT L265P WT WT WT
2 Non-GCB Non-GCB 80% + + Variable>50% + + + extracopy extracopy extracopy WT L265P WT WT WT
3 Non-GCB Non-GCB 70% + + Diffuse + + extracopy no split R273C L265P WT WT WT
  1. Abbreviations: GCB germinal center B cell, WT wild type