Table 1 Morphologic, Immunophenotypic, and Molecular Genetic Characteristics of 3 Patients With Primary CNS A-DLBCL
From: Rare cases of primary central nervous system anaplastic variant of diffuse large B-cell lymphoma
| Â | Cell of Origin | Immunohistochemistry | FISH | Mutation Statuses | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient | Hans | Choi | CD5 | CD30 | Ki-67 | BCL2 | MYC | P53 | RELA | RELB | c-Rel | MYC | BCL2 | BCL6 | TP53 | MYD88 | CD79B | CARD11 | EZH2 |
(exon 5–10) | (exon 5) | (exon 5) | (exon 5–9) | (exon 16) | |||||||||||||||
1 | GCB | GCB | – | + | 90% | + | + | All negative | + | + | + | extracopy | extracopy | extracopy | WT | L265P | WT | WT | WT |
2 | Non-GCB | Non-GCB | – | – | 80% | + | + | Variable>50% | + | + | + | extracopy | extracopy | extracopy | WT | L265P | WT | WT | WT |
3 | Non-GCB | Non-GCB | – | – | 70% | + | + | Diffuse | + | + | – | extracopy | no | split | R273C | L265P | WT | WT | WT |