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Table 2 Cox regression analyses of variables for OS and LFS in whole-cohort-AML among TCGA cohort

From: BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia

Variables OS LFS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
BCL2 expression 1.000 (1.000–1.000) 0.185 1.000 (1.000–1.000) 0.761 1.000 (1.000–1.000) 0.356   
Age 1.040 (1.027–1.054) 0.000 1.027 (1.011–1.042) 0.001 1.035 (1.022–1.048) 0.000 1.027 (1.013–1.041) 0.000
WBC 1.003 (0.999–1.006) 0.119 1.007 (1.003–1.012) 0.001 1.003 (1.000–1.006) 0.091 1.003 (1.000–1.006) 0.040
Karyotype risk 1.854 (1.465–2.346) 0.000 2.208 (1.591–3.063) 0.000 1.829 (1.448–2.311) 0.000 2.065 (1.593–2.676) 0.000
Treatment regimens 0.551 (0.389–0.780) 0.001 0.441 (0.284–0.687) 0.000 0.615 (0.434–0.871) 0.006 0.546 (0.366–0.815) 0.003
FLT3 mutations 1.269 (0.869–1.852) 0.217    1.254 (0.859–1.829) 0.241   
NPM1 mutations 1.220 (0.837–1.778) 0.301    1.268 (0.869–1.848) 0.218   
CEBPA mutations 0.913 (0.464–1.796) 0.792    1.053 (0.535–2.073) 0.881   
DNMT3A mutations 1.615 (1.104–2.362) 0.014 1.472 (0.951–2.279) 0.083 1.511 (1.035–2.206) 0.033 1.302 (0.860–1.973) 0.212
IDH1 mutations 0.843 (0.466–1.527) 0.574    0.890 (0.492–1.611) 0.700   
IDH2 mutations 1.113 (0.649–1.910) 0.697    0.987 (0.576–1.691) 0.963   
TET2 mutations 0.953 (0.514–1.767) 0.879    0.945 (0.510–1.751) 0.857   
RUNX1 mutations 1.853 (1.077–3.186) 0.026 1.692 (1.137–2.518) 0.009 1.644 (0.959–2.817) 0.071 1.322 (0.912–1.916) 0.141
TP53 mutations 3.687 (2.144–6.339) 0.000 2.379 (1.211–4.673) 0.012 3.257 (1.912–5.549) 0.000 1.642 (0.904–2.984) 0.103
  1. OS overall survival, LFS leukemia-free survival, HR hazard ratio, CI confidence interval, WBC white blood cells. Variables in multivariate analysis including BCL2 expression, age, WBC, karyotype (favorable vs. intermediate vs. poor), treatment regimens (without/with HSCT) and gene mutations (mutant vs. wild-type)