|Case||Age-Sex||Tumor site, description ± related circumstances||Histological findings||IHC profile within the metaplastic component||Treatment||Grade||Outcome||Reference|
Abdominal wall, midway between umbilicus and pubis symphisis: hard fibrous plaque of 2,2 × 1,6 × 1 cm with central bone formation, 4y. history of papillary urothelial bladder carcinoma with prostatic enlargement treated by transurethral|
bladder resections, cystodiathermy cauterizations and transvesical prostatectomy.
-Well differentiated papillary urothelial carcinoma surrounded by fibrous connective tissue, presumed as scar tissue; and muscle.|
-SOM characterized by well-formed bone.
|2||65y-M||Left supraclavicular region: firm and partially fixed mass, measuring 1,5 × 1,5 cm, 2y. after radiotherapy and partial cystectomy for a papillary urothelial bladder carcinoma.||Left supraclavicular region: fibro-adipose tissue with prominent metaplastic bone formation and several foci of malignant cells consistent with metastatic papillary urothelial carcinoma.||WNP||Irradiation.||3||NA|||
|Left tibia: extensive lysis and sclerosis of the entire tibial shaft, 1y. after supraclavicular metastatic localization.||Left tibia: poorly differentiated papillary urothelial carcinoma invading bone, soft tissue and striated muscle with metaplastic bone formation.|
Left femur proximal end: third metastatic focus, 8 m. after|
|Left femur proximal end: similar histological pattern to supraclavicular and tibial metastases.|
|3||54y-M||Left tibia: metastatic localization, 14 m. after primary tumor.||NA||NA||NA||NA||NA|||
Left tibia: metastatic localization with amorphous ossification|
in surrounding soft tissue, 14 m. after primary tumor.
|Metastatic papillary urothelial carcinoma with new bone.||NA||NA||NA||NA|||
|5||64y-F||Right femur, right and left tibiae: metastatic tumor with ill-defined bone destruction and heterotopic soft tissue ossification, 24 m. after primary tumor.||NA||NA||NA||NA||NA|||
|6||78y-M||Massive nodal metastases on radical cysto-prostatectomy with lymph node dissection specimens for urothelial bladder tumor.||Metastatic papillary urothelial carcinoma with osseous metaplasia seen only in lymph nodes.||NA||Radical cystoprostatectomy with lymph node dissection.||3||NA|||
. Nodal metastases on radical cysto-prostatectomy with bilateral ilio-obturator lymph node dissection specimens for urothelial bladder tumor.|
-Right retroperitoneal space: heterotopic bone formation, 1y. after surgery.
-Nodal metastases: poorly differentiated papillary urothelial carcinoma|
with small foci of mature lamellar-bone trabeculae, outlined by non atypical osteocytes.
-Right retroperitoneal space: Similar histological pattern to nodal metastases.
|WNP||Adjuvant chemotherapy and radiotherapy.||3||
-Alive with progressing lesions resistant to radiotherapy at the time of the report.|
-No further available follow-up.