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Table 2 Reported cases of SOM in metastatic papillary urothelial carcinoma of the bladder

From: Stromal osseous metaplasia in urothelial carcinoma of the bladder: a rare case report and literature review

Case Age-Sex Tumor site, description ± related circumstances Histological findings IHC profile within the metaplastic component Treatment Grade Outcome Reference
1 54y-M Abdominal wall, midway between umbilicus and pubis symphisis: hard fibrous plaque of 2,2 × 1,6 × 1 cm with central bone formation, 4y. history of papillary urothelial bladder carcinoma with prostatic enlargement treated by transurethral bladder resections, cystodiathermy cauterizations and transvesical prostatectomy. -Well differentiated papillary urothelial carcinoma surrounded by fibrous connective tissue, presumed as scar tissue; and muscle. -SOM characterized by well-formed bone. WNP Surgical resection. 1 NA [11]
2 65y-M Left supraclavicular region: firm and partially fixed mass, measuring 1,5 × 1,5 cm, 2y. after radiotherapy and partial cystectomy for a papillary urothelial bladder carcinoma. Left supraclavicular region: fibro-adipose tissue with prominent metaplastic bone formation and several foci of malignant cells consistent with metastatic papillary urothelial carcinoma. WNP Irradiation. 3 NA [12]
Left tibia: extensive lysis and sclerosis of the entire tibial shaft, 1y. after supraclavicular metastatic localization. Left tibia: poorly differentiated papillary urothelial carcinoma invading bone, soft tissue and striated muscle with metaplastic bone formation.
Left femur proximal end: third metastatic focus, 8 m. after tibial metastasis. Left femur proximal end: similar histological pattern to supraclavicular and tibial metastases.
3 54y-M Left tibia: metastatic localization, 14 m. after primary tumor. NA NA NA NA NA [13]
4 74y-F Left tibia: metastatic localization with amorphous ossification in surrounding soft tissue, 14 m. after primary tumor. Metastatic papillary urothelial carcinoma with new bone. NA NA NA NA [13]
5 64y-F Right femur, right and left tibiae: metastatic tumor with ill-defined bone destruction and heterotopic soft tissue ossification, 24 m. after primary tumor. NA NA NA NA NA [13]
6 78y-M Massive nodal metastases on radical cysto-prostatectomy with lymph node dissection specimens for urothelial bladder tumor. Metastatic papillary urothelial carcinoma with osseous metaplasia seen only in lymph nodes. NA Radical cystoprostatectomy with lymph node dissection. 3 NA [14]
7 75y-M . Nodal metastases on radical cysto-prostatectomy with bilateral ilio-obturator lymph node dissection specimens for urothelial bladder tumor. -Right retroperitoneal space: heterotopic bone formation, 1y. after surgery. -Nodal metastases: poorly differentiated papillary urothelial carcinoma with small foci of mature lamellar-bone trabeculae, outlined by non atypical osteocytes. -Right retroperitoneal space: Similar histological pattern to nodal metastases. WNP Adjuvant chemotherapy and radiotherapy. 3 -Alive with progressing lesions resistant to radiotherapy at the time of the report. -No further available follow-up. [3]