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Table 2 The relationship between MYC, BCL2 and BCL6 genetic alteration and clinical features

From: Prognostic impact of diffuse large B-cell lymphoma with extra copies of MYC, BCL2 and/or BCL6: comparison with double/triple hit lymphoma and double expressor lymphoma

 

MYC EC

BCL2 EC

BCL6 EC

Atypical DHL/THL

Atypical DHL/THL

DHL + THL

P

Atypical DHL/THL

DEL

P

+

–

P

+

–

P

+

–

P

+

–

P

n(%)

n(%)

 

n(%)

n(%)

 

n (%)

n(%)

 

n(%)

n(%)

 

n(%)

n(%)

 

n(%)

n(%)

 

n = 82

n = 81

n = 78

n = 49

n = 18

n = 32

Age

 Median (range)

60(18–69)

61(2–86)

 

61(2–80)

60 (18–86)

 

57 (28–82)

63(2–86)

 

61(28–69)

63(29–86)

 

61(28–69)

60 (54–73)

 

61(28–69)

63(28–86)

 

 > 60

4(36.4)

37(52.1)

0.519*

11(52.4)

29(48.3)

0.749

7(38.9)

35(58.3)

0.147

5(50.0)

23(59.0)

0.609

5(50.0)

3(37.5)

0.664*

5(50.0)

12(54.5)

0.811

Sex

 Male

6(54.5)

30(42.3)

0.445

12(57.1)

24(40.0)

0.174

12(66.7)

24(40.0)

0.047

6(60.0)

13(33.3)

0.156*

6(60.0)

5(62.5)

> 0.999*

4(40.0)

9(40.9)

> 0.999*

 Female

5(45.5)

41(57.7)

 

9(42.9)

36(60.0)

 

6(33.3)

36(60.0)

 

4(40.0)

26(66.7)

 

4(40.0)

3(37.5)

 

6(60.0)

13(59.1)

 

 Ann Arbor stage> 2

10(90.9)

51(71.8)

0.274*

17(81.0)

43(71.7)

0.565*

14(77.8)

43(71.7)

0.766*

9(90.0)

26(66.7)

0.244*

9(90.0)

8(100.0)

> 0.999*

9(90.0)

16(72.7)

0.387*

 Extranodal sites≥2

6(54.5)

38(53.5)

0.949

14(66.7)

32(53.3)

0.288

11(61.1)

31(51.7)

0.481

5(50.0)

19(48.7)

0.942

5(50.0)

6(75.0)

0.367*

5(50.0)

12(54.5)

0.811

 Elevated serum LDH

7(63.6)

33(47.8)

0.518*

9(45.0)

32(54.2)

0.475

9(52.9)

26(44.1)

0.518

6(60.0)

19(48.7)

0.725*

6(60.0)

5(62.5)

> 0.999*

6(60.0)

14(66.7)

> 0.999*

 ECOG PS ≥ 2

2(18.2)

13(18.3)

> 0.999*

5(23.8)

13(21.7)

0.839

4(22.2)

11(18.3)

0.739*

2(20.0)

7(17.9)

> 0.999*

2(20.0)

5(62.5)

0.145*

2(20.0)

3(13.6)

0.637*

 IPI ≥ 3

7(63.6)

35(49.3)

0.520*

11(52.4)

33(55.0)

0.836

9(50.0)

31(51.7)

0.901

6(60.0)

18(46.2)

0.496*

6(60.0)

7(87.5)

0.314*

6(60.0)

13(59.1)

> 0.999*

 B symptoms

9(81.8)

29(40.8)

0.020*

13(61.9)

26(43.3)

0.143

9(50.0)

28(46.7)

0.804

7(70.0)

16(41.0)

0.157*

7(70.0)

6(75.0)

> 0.999*

7(70.0)

10(45.5)

0.265*

 Marrow involvement

3(27.3)

6(8.5)

0.097*

7(33.3)

3(5.0)

0.002*

4(22.2)

9(15.0)

0.483*

4(40.0)

1(2.6)

0.004*

4(40.0)

6(75.0)

0.188*

4(40.0)

4(18.2)

0.218*

 Nervous involvement

2(18.2)

7(9.9)

0.347*

5(23.8)

5(8.3)

0.064

2(11.1)

4(6.7)

0.617*

2(20.0)

2(5.1)

0.180*

2(20.0)

1(12.5)

> 0.999*

2(20.0)

2(9.1)

0.572*

Treatment

 R-CHOP

7(63.6)

35(49.3)

 

12(57.1)

29(48.3)

 

8(44.4)

33(55.0)

 

6(60.0)

21(53.8)

0.444

6(60.0)

5(62.5)

0.460

6(60.0)

9(40.9)

0.662

 R-CHOPE

4(36.4)

24(33.8)

 

8(38.1)

19(31.7)

 

7(38.9)

19(31.7)

 

4(40.0)

10(2.6)

 

4(40.0)

2(25.0)

 

4(40.0)

11(50.0)

 

 Resection

0(0)

10(14.1)

 

1(4.8)

9(15.0)

 

2(11.1)

7(11.7)

 

0(0)

7(17.9)

 

0(0)

0(0)

 

0(0)

1(4.5)

 

 No therapy

0(0)

2(2.8)

 

0(0)

3(5.0)

 

1(5.6)

1(1.7)

 

0(0)

1(2.6)

 

0(0)

1(12.5)

 

0(0)

1(4.5)

 

 ASCT (total)

2(18.2)

12(16.9)

> 0.999*

3(14.3)

10(16.7)

> 0.999*

2(11.1)

9(15.0)

> 0.999*

1(10.0)

4(10.3)

> 0.999*

1(10.0)

2(25.0)

0.559*

1(10.0)

6(27.3)

0.387*

Treatment response

 CR

5(45.5)

37(55.2)

0.132

9(42.9)

32(57.1)

0.458

9(56.3)

30(51.7)

0.786

5(50.0)

21(56.8)

0.071

5(50.0)

1(12.5)

0.207

5(50.0)

10(47.6)

0.096

 PR

3(27.3)

25(37.3)

 

8(38.1)

18(32.1)

 

5(31.3)

23(39.7)

 

2(20.0)

14(37.8)

 

4(50.0)

2(20.0)

 

2(20.0)

10(47.6)

 

 SD

3(27.3)

5(7.5)

 

4(19.0)

6(10.7)

 

2(12.5)

5(8.6)

 

3(30.0)

2(5.4)

 

3(30.0)

3(37.5)

 

3(30.0)

1(4.8)

 

 Relapse

3(27.3)

10(14.7)

0.377*

4(19.0)

11(19.3)

> 0.999*

4(23.5)

9(15.5)

0.475*

3(30.0)

6(16.2)

0.377*

3(30.0)

3(37.5)

> 0.999*

3(30.0)

2(9.5)

0.296*

  1. EC extra copies, DHL double hit lymphoma, THL triple hit lymphoma, DEL double expressor lymphoma, LDH lactate dehydrogenase, ECOG Eastern Cooperative Oncology Group, PS performance status, IPI international prognostic index, ASCT autologous stem cell transplantation, CR complete response/remission, PR partial response/remission, SD,stable disease
  2. *Fisher’s exact test