| MYC EC | BCL2 EC | BCL6 EC | Atypical DHL/THL | Atypical DHL/THL | DHL + THL | P | Atypical DHL/THL | DEL | P | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
+ | – | P | + | – | P | + | – | P | + | – | P | |||||||
n(%) | n(%) | Â | n(%) | n(%) | Â | n (%) | n(%) | Â | n(%) | n(%) | Â | n(%) | n(%) | Â | n(%) | n(%) | Â | |
n = 82 | n = 81 | n = 78 | n = 49 | n = 18 | n = 32 | |||||||||||||
Age | ||||||||||||||||||
 Median (range) | 60(18–69) | 61(2–86) |  | 61(2–80) | 60 (18–86) |  | 57 (28–82) | 63(2–86) |  | 61(28–69) | 63(29–86) |  | 61(28–69) | 60 (54–73) |  | 61(28–69) | 63(28–86) |  |
 > 60 | 4(36.4) | 37(52.1) | 0.519* | 11(52.4) | 29(48.3) | 0.749 | 7(38.9) | 35(58.3) | 0.147 | 5(50.0) | 23(59.0) | 0.609 | 5(50.0) | 3(37.5) | 0.664* | 5(50.0) | 12(54.5) | 0.811 |
Sex | ||||||||||||||||||
 Male | 6(54.5) | 30(42.3) | 0.445 | 12(57.1) | 24(40.0) | 0.174 | 12(66.7) | 24(40.0) | 0.047 | 6(60.0) | 13(33.3) | 0.156* | 6(60.0) | 5(62.5) | > 0.999* | 4(40.0) | 9(40.9) | > 0.999* |
 Female | 5(45.5) | 41(57.7) |  | 9(42.9) | 36(60.0) |  | 6(33.3) | 36(60.0) |  | 4(40.0) | 26(66.7) |  | 4(40.0) | 3(37.5) |  | 6(60.0) | 13(59.1) |  |
 Ann Arbor stage> 2 | 10(90.9) | 51(71.8) | 0.274* | 17(81.0) | 43(71.7) | 0.565* | 14(77.8) | 43(71.7) | 0.766* | 9(90.0) | 26(66.7) | 0.244* | 9(90.0) | 8(100.0) | > 0.999* | 9(90.0) | 16(72.7) | 0.387* |
 Extranodal sites≥2 | 6(54.5) | 38(53.5) | 0.949 | 14(66.7) | 32(53.3) | 0.288 | 11(61.1) | 31(51.7) | 0.481 | 5(50.0) | 19(48.7) | 0.942 | 5(50.0) | 6(75.0) | 0.367* | 5(50.0) | 12(54.5) | 0.811 |
 Elevated serum LDH | 7(63.6) | 33(47.8) | 0.518* | 9(45.0) | 32(54.2) | 0.475 | 9(52.9) | 26(44.1) | 0.518 | 6(60.0) | 19(48.7) | 0.725* | 6(60.0) | 5(62.5) | > 0.999* | 6(60.0) | 14(66.7) | > 0.999* |
 ECOG PS ≥ 2 | 2(18.2) | 13(18.3) | > 0.999* | 5(23.8) | 13(21.7) | 0.839 | 4(22.2) | 11(18.3) | 0.739* | 2(20.0) | 7(17.9) | > 0.999* | 2(20.0) | 5(62.5) | 0.145* | 2(20.0) | 3(13.6) | 0.637* |
 IPI ≥ 3 | 7(63.6) | 35(49.3) | 0.520* | 11(52.4) | 33(55.0) | 0.836 | 9(50.0) | 31(51.7) | 0.901 | 6(60.0) | 18(46.2) | 0.496* | 6(60.0) | 7(87.5) | 0.314* | 6(60.0) | 13(59.1) | > 0.999* |
 B symptoms | 9(81.8) | 29(40.8) | 0.020* | 13(61.9) | 26(43.3) | 0.143 | 9(50.0) | 28(46.7) | 0.804 | 7(70.0) | 16(41.0) | 0.157* | 7(70.0) | 6(75.0) | > 0.999* | 7(70.0) | 10(45.5) | 0.265* |
 Marrow involvement | 3(27.3) | 6(8.5) | 0.097* | 7(33.3) | 3(5.0) | 0.002* | 4(22.2) | 9(15.0) | 0.483* | 4(40.0) | 1(2.6) | 0.004* | 4(40.0) | 6(75.0) | 0.188* | 4(40.0) | 4(18.2) | 0.218* |
 Nervous involvement | 2(18.2) | 7(9.9) | 0.347* | 5(23.8) | 5(8.3) | 0.064 | 2(11.1) | 4(6.7) | 0.617* | 2(20.0) | 2(5.1) | 0.180* | 2(20.0) | 1(12.5) | > 0.999* | 2(20.0) | 2(9.1) | 0.572* |
Treatment | ||||||||||||||||||
 R-CHOP | 7(63.6) | 35(49.3) |  | 12(57.1) | 29(48.3) |  | 8(44.4) | 33(55.0) |  | 6(60.0) | 21(53.8) | 0.444 | 6(60.0) | 5(62.5) | 0.460 | 6(60.0) | 9(40.9) | 0.662 |
 R-CHOPE | 4(36.4) | 24(33.8) |  | 8(38.1) | 19(31.7) |  | 7(38.9) | 19(31.7) |  | 4(40.0) | 10(2.6) |  | 4(40.0) | 2(25.0) |  | 4(40.0) | 11(50.0) |  |
 Resection | 0(0) | 10(14.1) |  | 1(4.8) | 9(15.0) |  | 2(11.1) | 7(11.7) |  | 0(0) | 7(17.9) |  | 0(0) | 0(0) |  | 0(0) | 1(4.5) |  |
 No therapy | 0(0) | 2(2.8) |  | 0(0) | 3(5.0) |  | 1(5.6) | 1(1.7) |  | 0(0) | 1(2.6) |  | 0(0) | 1(12.5) |  | 0(0) | 1(4.5) |  |
 ASCT (total) | 2(18.2) | 12(16.9) | > 0.999* | 3(14.3) | 10(16.7) | > 0.999* | 2(11.1) | 9(15.0) | > 0.999* | 1(10.0) | 4(10.3) | > 0.999* | 1(10.0) | 2(25.0) | 0.559* | 1(10.0) | 6(27.3) | 0.387* |
Treatment response | ||||||||||||||||||
 CR | 5(45.5) | 37(55.2) | 0.132 | 9(42.9) | 32(57.1) | 0.458 | 9(56.3) | 30(51.7) | 0.786 | 5(50.0) | 21(56.8) | 0.071 | 5(50.0) | 1(12.5) | 0.207 | 5(50.0) | 10(47.6) | 0.096 |
 PR | 3(27.3) | 25(37.3) |  | 8(38.1) | 18(32.1) |  | 5(31.3) | 23(39.7) |  | 2(20.0) | 14(37.8) |  | 4(50.0) | 2(20.0) |  | 2(20.0) | 10(47.6) |  |
 SD | 3(27.3) | 5(7.5) |  | 4(19.0) | 6(10.7) |  | 2(12.5) | 5(8.6) |  | 3(30.0) | 2(5.4) |  | 3(30.0) | 3(37.5) |  | 3(30.0) | 1(4.8) |  |
 Relapse | 3(27.3) | 10(14.7) | 0.377* | 4(19.0) | 11(19.3) | > 0.999* | 4(23.5) | 9(15.5) | 0.475* | 3(30.0) | 6(16.2) | 0.377* | 3(30.0) | 3(37.5) | > 0.999* | 3(30.0) | 2(9.5) | 0.296* |