Fig. 2

HV-LPD morphology and immunophenotype of case 10. a Skin biopsy shows edema and vesicles in the epidermis (hematoxylin and eosin [H&E], 40×). b Skin biopsy shows an infiltration of atypical lymphocytes surrounding adnexa and blood vessels (H&E, 200×). c Immunohistochemical CD8 stain shows that the cells surrounding the adnexa and blood vessels are strongly CD8-positive (200×). d In situ hybridization for EBV-encoded RNA showed positive signals in infiltrating lymphocytes (200×)