Multinucleated stromal giant cells in the gastroesophageal junctional and gastric mucosa: a retrospective study

Diagnostic Pathology

Table 1 Clinicopathologic Features of Gastroesophageal Specimens with Multinucleated Stromal Giant Cells

Case	Indication for Procedure	Pathology Diagnosis	Immunohistochemistry^a
			SMA	Desmin
1	Belching	Chronic inactive gastritis	+	+
2	GERD	CAI, REC	+/−	+/−
3	Alcohol abuse	RCG	+	+
4	Abdominal pain	CAI, PACM	+	+
5	Obesity S/P bypass	BE	+	+/−
6	Dysphagia	PACM, chronic inflammation	+	+/−
7	Esophagitis	BE, CAI, REC	+	+
8	Esophageal ulcer	ACG,RCG	+	+
9	BE, GERD	RCG	+	+
10	Abdominal pain	RCG	+	+
11	Obesity, heart burn	GERD	+	+/−
12	BE, GERD	REC, chronic inflammation	+	+
13	Epigastric pain	Active chronic gastritis, IM	+	+
14	BE with HGD	Rare AI	+	+
15	BE with LGD	CAI, REC, GERD	+	+
16	S/P resection for esophageal CA	Radiation atypia, REC, CAI	+/−	+
17	S/P resection for GEJ CA	Radiation atypia, BE with HGD	+	+
18	GERD, gastric CA	CAI, IM, luminal yeast/bacteria	+	+
19	Chronic gastritis, ulcer	CAI	+	+
20	GERD	PACM, chronic inflammation	+	+
21	Epigastric pain	RCG, chronic inflammation	+	+
22	Epigastric pain	No significant change	+	+

Abbreviations: GERD gastroesophageal reflux disease, BE Barrett’s esophagus, HGD high grade dysplasia, LGD low grade dysplasia, CA carcinoma, GEJ gastroesophageal junction, REC reactive epithelial changes, CAI chronic and acute inflammation, RCG reactive (chemical) gastropathy, PACM pancreatic acinar cell metaplasia, IM intestinal metaplasia, S/P status post
^aThe multinucleated stromal giant cells do not express cytokeratin AE1/3, chromogranin, CD68, CD117, and S100

ISSN: 1746-1596