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Table 1 Clinicopathologic Features of Gastroesophageal Specimens with Multinucleated Stromal Giant Cells

From: Multinucleated stromal giant cells in the gastroesophageal junctional and gastric mucosa: a retrospective study

CaseIndication for ProcedurePathologyDiagnosisImmunohistochemistrya
   SMADesmin
1BelchingChronic inactive gastritis++
2GERDCAI, REC+/−+/−
3Alcohol abuseRCG++
4Abdominal painCAI, PACM++
5Obesity S/P bypassBE++/−
6DysphagiaPACM, chronic inflammation++/−
7EsophagitisBE, CAI, REC++
8Esophageal ulcerACG,RCG++
9BE, GERDRCG++
10Abdominal painRCG++
11Obesity, heart burnGERD++/−
12BE, GERDREC, chronic inflammation++
13Epigastric painActive chronic gastritis, IM++
14BE with HGDRare AI++
15BE with LGDCAI, REC, GERD++
16S/P resection for esophageal CARadiation atypia, REC, CAI+/−+
17S/P resection for GEJ CARadiation atypia, BE with HGD++
18GERD, gastric CACAI, IM, luminal yeast/bacteria++
19Chronic gastritis, ulcerCAI++
20GERDPACM, chronic inflammation++
21Epigastric painRCG, chronic inflammation++
22Epigastric painNo significant change++
  1. Abbreviations: GERD gastroesophageal reflux disease, BE Barrett’s esophagus, HGD high grade dysplasia, LGD low grade dysplasia, CA carcinoma, GEJ gastroesophageal junction, REC reactive epithelial changes, CAI chronic and acute inflammation, RCG reactive (chemical) gastropathy, PACM pancreatic acinar cell metaplasia, IM intestinal metaplasia, S/P status post
  2. aThe multinucleated stromal giant cells do not express cytokeratin AE1/3, chromogranin, CD68, CD117, and S100