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Table 1 Clinicopathologic Features and Genotyping Data in 15 choriocarcinomas

From: Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series

Case N Age (y) Clinical Presentation β-hCG at Presentation (mIU/mL) gestation history antecedent gestation Specimen Diagnosis Genotyping causative pregnancy Therapy, Disease Status, Follow-up (mo)
1 28 Vaginal bleeding, 2770 G4P1
Term(2 y ago)
IA(3y,1y ago)
Missed abortion (2 monthes ago) Hysterectomy
tumor
CC Gestational
Biparental,XX
abortion/ term TP (4 cycles); +EME-CO (4 cycles);+EP-EMA(3 cycles)+
Hysterectomy; NED (33)
2 32 Vaginal bleeding, 37,382 G3P1
Term(10 y ago)
MA(8 y ago)
Missed abortion (4 monthes ago) Uterine curetting CC Gestational, androgenetic, XX Occult Homozygous
CHM
TP (2 cycles)
NED (25)
3 32 Vaginal bleeding, 6067 G4P2
Pre tern(13 y ago)
Term(12,2y ago)
Missed abortion (14 monthes ago) Uterine curetting CC Gestational
Biparental,XY
missed abortion
/ term
TP (4 cycles); +EME-CO (6 cycles);+ Hysterectomy
NED (44)
4 10 lower abdominal,
pain; Vaginal bleeding,
297,475 G0P0 no Ovary, pelvic tumor CC Nongestational (tumor matches maternal tissue) no BEP(6 cycles)
Lost to follow-up(6)
5 55 Vaginal bleeding, 531 G3P1 CHM,(7 y ago) Uterine curetting
+ mole
CC Gestational, androgenetic, XX antecedent
Homozygous
CHM
MTX(3 cycles), Hysterectomy,
NED(23)
6 34 Vaginal bleeding, 22,586 G2P2
Term(12 y ago)
Term(4 weeks ago) Uterine curetting
+ placenta
CC Gestational Biparental,XY Term
pregnancy
EME-CO (7 cycles)
NED (23)
7 37 rising β-HCG 98 G3P2,
CHM(7 y ago)
Term(5 y ago) Uterine curetting CC Gestational, androgenetic, XX Heterzygous
CHM
EME-CO (7 cycles)
NED (23)
8 37 lower abdominal pain 118 G5P1
Term(10 y ago)
SA(12y、5 y ago)
IA(13y、2 y ago)
IA(2 y ago) Right ovary CC Gestational, androgenetic XX Occult Homozygous
CHM
EME-CO (7 cycles)
NED (29)
9 23 rising β-HCG 160 G2P1 CHM,(9 monthes ago) Uterine curetting CC Gestational, androgenetic, XX Homozygous
CHM
MTX(4 cycles), 5-FU* (4 cycles),
EMA-CO (4 cycles)
NED (45)
10 21 lower abdominal pain > 800,000 G0P0 no Pelvic tumor
+Concurrent placenta
CC Gestational, (biparental XY+
Androgenetic XX)
Occult Homozygous
CHM/ twim one
CHM
EMA-CO (3 cycles)
Termination chemothrapy,
NED (51)
11 20 Vaginal bleeding, 18,973 G0P0 no Right ovary CC Gestational,
Biparental,XY
Occult
SP
EMA-CO (7 cycles)
NED (60)
12 35 Vaginal bleeding, + rising β-HCG 14,774 G6P2 DA(10y,10y,12y,
12y ago)
Term(5y ago)
Term(8 weeks ago) Uterine curetting CC Gestational, androgenetic, XX Occult Heterzygous
CHM
MTX(3 cycles) + ACTD(5 cycles)
NED (10)
13 31 Vaginal bleeding, > 1000 G1P1 Term(12 weeks ago) Uterine curetting CC Gestational,
Biparental,XX
Term
pregnancy
EMA (6ycles) + TP (4ycles)
NED (8)
14 54 lower abdominal pain 9135 G4P1 IA(32y,
31y,28y,ago)
Term(29y ago)
CHM,(2 monthes ago) Uterine curetting CC Gestational, androgenetic, XX Homozygous
CHM
EMA-CO(2 cycles) +
TP(2 cycles) + Hysterectomy
NED (5)
15 28 Vaginal bleeding 21,154 G6P1 IA(5y,
4y,3y,2y,2y ago)
Term(8 weeks ago) Uterine curetting CC Gestational, androgenetic, XX Occult Homozygous
CHM
MTX (4 cycles)
NED (7)
  1. BEP bleomycin, etoposide, cisplatin, CC Choriocarcinoma, DA drug abortion, EMA etoposide, methotrexate, actinomycin D, EMA-CO etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine, IA induced abortion, MA missed abortion, NED no evidence of disease, SA spontaneous abortion, TP, paclitaxel-cisplatin