Table 1 Clinicopathologic Features and Genotyping Data in 15 choriocarcinomas
From: Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series
Case N | Age (y) | Clinical Presentation | β-hCG at Presentation (mIU/mL) | gestation history | antecedent gestation | Specimen | Diagnosis | Genotyping | causative pregnancy | Therapy, Disease Status, Follow-up (mo) |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 28 | Vaginal bleeding, | 2770 | G4P1 Term(2 y ago) IA(3y,1y ago) | Missed abortion (2 monthes ago) | Hysterectomy tumor | CC | Gestational Biparental,XX | abortion/ term | TP (4 cycles); +EME-CO (4 cycles);+EP-EMA(3 cycles)+ Hysterectomy; NED (33) |
2 | 32 | Vaginal bleeding, | 37,382 | G3P1 Term(10 y ago) MA(8 y ago) | Missed abortion (4 monthes ago) | Uterine curetting | CC | Gestational, androgenetic, XX | Occult Homozygous CHM | TP (2 cycles) NED (25) |
3 | 32 | Vaginal bleeding, | 6067 | G4P2 Pre tern(13 y ago) Term(12,2y ago) | Missed abortion (14 monthes ago) | Uterine curetting | CC | Gestational Biparental,XY | missed abortion / term | TP (4 cycles); +EME-CO (6 cycles);+ Hysterectomy NED (44) |
4 | 10 | lower abdominal, pain; Vaginal bleeding, | 297,475 | G0P0 | no | Ovary, pelvic tumor | CC | Nongestational (tumor matches maternal tissue) | no | BEP(6 cycles) Lost to follow-up(6) |
5 | 55 | Vaginal bleeding, | 531 | G3P1 | CHM,(7 y ago) | Uterine curetting + mole | CC | Gestational, androgenetic, XX | antecedent Homozygous CHM | MTX(3 cycles), Hysterectomy, NED(23) |
6 | 34 | Vaginal bleeding, | 22,586 | G2P2 Term(12 y ago) | Term(4 weeks ago) | Uterine curetting + placenta | CC | Gestational Biparental,XY | Term pregnancy | EME-CO (7 cycles) NED (23) |
7 | 37 | rising β-HCG | 98 | G3P2, CHM(7 y ago) | Term(5 y ago) | Uterine curetting | CC | Gestational, androgenetic, XX | Heterzygous CHM | EME-CO (7 cycles) NED (23) |
8 | 37 | lower abdominal pain | 118 | G5P1 Term(10 y ago) SA(12y、5 y ago) IA(13y、2 y ago) | IA(2 y ago) | Right ovary | CC | Gestational, androgenetic XX | Occult Homozygous CHM | EME-CO (7 cycles) NED (29) |
9 | 23 | rising β-HCG | 160 | G2P1 | CHM,(9 monthes ago) | Uterine curetting | CC | Gestational, androgenetic, XX | Homozygous CHM | MTX(4 cycles), 5-FU* (4 cycles), EMA-CO (4 cycles) NED (45) |
10 | 21 | lower abdominal pain | > 800,000 | G0P0 | no | Pelvic tumor +Concurrent placenta | CC | Gestational, (biparental XY+ Androgenetic XX) | Occult Homozygous CHM/ twim one CHM | EMA-CO (3 cycles) Termination chemothrapy, NED (51) |
11 | 20 | Vaginal bleeding, | 18,973 | G0P0 | no | Right ovary | CC | Gestational, Biparental,XY | Occult SP | EMA-CO (7 cycles) NED (60) |
12 | 35 | Vaginal bleeding, + rising β-HCG | 14,774 | G6P2 DA(10y,10y,12y, 12y ago) Term(5y ago) | Term(8 weeks ago) | Uterine curetting | CC | Gestational, androgenetic, XX | Occult Heterzygous CHM | MTX(3 cycles) + ACTD(5 cycles) NED (10) |
13 | 31 | Vaginal bleeding, | > 1000 | G1P1 | Term(12 weeks ago) | Uterine curetting | CC | Gestational, Biparental,XX | Term pregnancy | EMA (6ycles) + TP (4ycles) NED (8) |
14 | 54 | lower abdominal pain | 9135 | G4P1 IA(32y, 31y,28y,ago) Term(29y ago) | CHM,(2 monthes ago) | Uterine curetting | CC | Gestational, androgenetic, XX | Homozygous CHM | EMA-CO(2 cycles) + TP(2 cycles) + Hysterectomy NED (5) |
15 | 28 | Vaginal bleeding | 21,154 | G6P1 IA(5y, 4y,3y,2y,2y ago) | Term(8 weeks ago) | Uterine curetting | CC | Gestational, androgenetic, XX | Occult Homozygous CHM | MTX (4 cycles) NED (7) |