Table 1 Reviews of Chinese cases of gynecological myeloid sarcoma
No | Author | Age | Time of genital involvement | Non-systemic involvement | Systemic involvement | AML Type | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|
Vulva | ||||||||
1 | Huang et al. [17] | 78 | Initial | None | Simultaneously | NA | Refused | Not stated |
2 | Yang et al. [18] | 27 | Initial | None | Simultaneously | M2 | CT (DNR + ARA-C) | CR, ANEL 36 mo |
3 | He et al. [19] | 25 | Initial | Pelvic LA | Simultaneously | M5 | Refused | Not stated |
4 | Hu et al. [20] | 45 | Relapse (MDS) | Perirenal | After 1.4 mo of vulvar MS | M5 | CT (ARA-C + IDA) | CR, died 3 mo (sepsis) |
5 | Fang et al. [21] | 75 | Isolated | Pulmonary SCC | None | NA | CT (HHT + ARA-C) → RT | MS resolved, relapse 10 mo later |
6 | Our case | 47 | Initial | None | Simultaneously | M2 | CT (ARA-C + IDA, ARA-C) II (ARA-C + MTX) | CR, ANEL 27 mo |
Vagina | ||||||||
7 | Li et al. [22] | 55 | Isolated | None | None | NA | SG → Refused | Died 10 mo |
8 | Xue et al. [23] | 61 | Not stated | Regional LA | Not stated | M2 | Not stated | Not stated |
Uterine cervix | ||||||||
9 | Lu et al. [24] | 41 | Initial | None | After 19 d of SG | M2 | SG → CT | Died 27d (cerebral hemorrhage) |
10 | Qu et al. [25] | 28 | Initial | None | Simultaneously | M2b | Not stated | Not stated |
11 | Zhang et al. [26] | 45 | Initial | None | Simultaneously | Not stated | CT (DNR + ARA-C) | Not stated |
12 | Wen et al. [27] | 49 | Not stated | Not stated | Not stated | NA | RT | Died 2 mo |
13 | Feng et al. [28] | 40 | Isolated | None | None | NA | SG | Not stated |
14 | Gao et al. [29] | 34 | Isolated | None | None | NA | CT (ARA-C + DNR) → SG → CT (ARA-C + DNR) | ANEL |
15 | Li et al. [30] | 34 | Isolated | None | None | NA | CT (DNR + ARA-C) → SG | ANEL |
16 | Zheng et al. [31] | 43 | Isolated | None | None | NA | CT (HHT + ARA-C) | ANEL 20 mo |
17 | Li et al. [22] | 46 | Isolated | None | None | NA | SG → CT (DNR + ARA-C) | ANEL 8 mo |
18 | Gu et al. [32] | 42 | Isolated | None | None | NA | CT (DNR + ARA-C) | ANEL 3 mo |
19 | Yu et al. [33] | 28 | Isolated | None | None | NA | CT (IDA + ARA-C) | Died 18 mo |
20 | Liu et al. [34] | 27 | Isolated | None | None | NA | SG | ANEL 15 mo |
21 | Zhang et al. [35] | 23 | Relapse (AML) | None | After 1 mo of MS | M2 | CT (ARA-C + MIT) | CR |
22 | Liu et al. [36] | 46 | Secondary | supramaxilla, breast | After 18 mo of MS | Not stated | CT (DNR + ARA-C, HHT + ARA-C, MIT + ARA-C) → pelvic RT | Died 4 mo after cessation of CT |
23 | Zhu et al. [37] | 63 | Not stated | Not stated | None | NA | CT → RT | CR |
24 | Zhu et al. [37] | 45 | Not stated | Not stated | None | NA | CT → SG | Died |
25 | Xue et al. [23] | 46 | Not stated | Head, neck, regional LA | Not stated | NA | Not stated | Not stated |
26 | Zuo et al. [38] | 42 | Initial | None | AML during CT | Not stated | SG → CT (DNR + ARA-C) | Died 12 mo |
27 | Zuo et al. [38] | 51 | Isolated | None | None | NA | CT → SG → CT (DNR + ARA-C) → gingiva 55 mo later → CT + RT + Allo-HSCT | Alive 91 mo |
28 | Feng et al. [39] | 57 | Isolated | None | None | NA | SG → Refused | ANEL 6 mo |
29 | Liu et al. [40] | 50 | Not stated | Pelvic LA | Not stated | NA | SG | Not stated |
30 | Wang et al. [41] | 28 | Initial | None | After 5 mo of MS | M2a | CT | CR, died 20 mo |
Uterine body | ||||||||
31 | Wang et al. [42] | 38 | Isolated | None | None | NA | SG | Not stated |
32 | Zhao et al. [43] | 33 | Isolated | None | None | NA | CT (DNR + ARA-C) | Alive |
33 | Hou et al. [44] | 44 | Isolated | None | None | NA | Not stated | Not stated |
Ovary | ||||||||
34 | Zhang et al. [45] | 27 | Initial | None | Simultaneously | M2 | CT (DNR + ARA-C) | PR, MS resolved |
35 | Zheng et al. [46] | 26 | Isolated | None | None | NA | SG → CT (DNR + ARA-C) → Auto-HSCT | ANEL 1 y after HSCT |
36 | Yu et al. [47] | 35 | Isolated | None | None | NA | SG → CT | ANEL 3 y 9 mo |
37 | Yu et al. [47] | 26 | Relapse (AML) | None | None | NA | SG | Not stated |
38 | Yu et al. [47] | 24 | Isolated | None | None | NA | SG → CT | ANEL 5 mo |
39 | Zhou et al. [48] | 27 | Initial | None | After 2 mo of MS | M2 | SG → CT (DNR + ARA-C) | Not stated |
40 | Zhou et al. [49] | 36 | Isolated | None | None | NA | SG → CT (DNR + ARA-C) | Not stated |
41 | Zhu et al. [37] | 23 | Isolated | None | None | NA | CT (ARA-C) | PR |
42 | Zhou et al. [50] | 27 | Not stated | Not stated | Not stated | NA | SG | Not stated |
43 | Pang et al. [51] | 23 | Isolated | None | None | NA | CT → RT | Died 39 mo |
44 | Pang et al. [51] | 22 | Relapse (AML-M3) | None | Not stated | NA | CT | Died 38 mo |
45 | Zhou et al. [48] | 36 | Not stated | Lung, small intestine, brain | None | NA | CT (VP-16 + ARA-C) | Died 1 mo (cerebral hemorrhage) |
46 | Wang et al. [41] | 26 | Secondary | Small intestine | None | NA | SG → CT | MS resolved, ANEL 15 mo |
Multifocal | ||||||||
47 | Zhang et al. [52] | 29 | Initial (vulva, ovary) | Whole body | Not stated | NA | Refused | Died 1 mo |
48 | Cheng et al. [53] | 37 | Initial (uterine cervix, ovary) | Right common iliac lymph nodes | After 6 mo of MS | Not stated | SG → CT (DNR + ARA-C, DNR + ARA-C+ Vm-26) → nasopharyngeal TCL → AML → CT (CTX + ADM + VCR + PED+Vm-26) | Metastasis to chest wall and anterior mediastinum |
49 | Qu et al. [54] | 44 | Relapse (AML-M2a) (uterine body, cervix) | None | None | NA | SG → CT | ANEL 1 y |
50 | Li et al. [55] | 43 | uterine body, cervix, vagina | Iliac perivascular LAP | None | NA | CT (PTX + PDD) → RT + CT (DNR + ARA-C) | MS resolved, ANEL 6 mo after cessation of CT |
51 | Wu et al. [56] | 25 | Uterine cervix, vagina | None | None | NA | CT (IDA + ARA-C) | CR, ANEL 3 mo |
52 | Wang et al. [57] | 43 | Uterine cervix, vagina | None | None | NA | CT (DNR + ARA-C, ARA-C, FA + ARA-C+ G-CSF), II (MTX + ARA-C + DXM) | Cervical MS resolved, ANEL 7 mo |
53 | Long et al. [58] | 46 | Relapse (AML-M2) (ovary, uterine cervix) | None | 1 mo after SG | M2 | SG → CT (MTX + VP16 + ARA-C) | ANEL 8 mo |
54 | Huang et al. [59] | 43 | Uterine cervix, left appendage | None | None | NA | CT | Died 11 mo |
55 | Xu et al. [60] | 51 | Ovary, uterus | Colon, rectum | Not stated | NA | SG, refused | Not stated |