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Table 4 Heterogeneity of PRMT1, ZEB1, RUNX1 and TWIST1 immunohistochemical expression among different tumor types

From: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Histological subtype PRMT1 ZEB1 RUNX1 TWIST1  
  + +/− + +/− + +/− + −/+
ccRCC 24 (20.0) 49 (40.8) 47 (39.2) 4 (3.5) 32 (27.8) 79 (68.7) 12 (10.2) 58 (49.6) 47 (40.2) 51 (43.6) 63 (53.8) 3 (2.6)
pRCC I 2 (28.6) 2 (28.6) 3 (42.9) 0 (0.0) 0 (0.0) 7 (100) 0 (0.0) 2 (28.6) 5 (71.4) 4 (57.2) 3 (42.8) 0 (0.0)
pRCC II 3 (18.8) 9 (56.2) 4 (25.0) 0 (0.0) 1 (6.3) 15 (93.8) 0 (0.0) 7 (43.7) 9 (56.3) 11 (64.6) 5 (29.4) 0 (0.0)
chRCC 7 (25.0) 5 (17.9) 16 (57.1) 0 (0.0) 2 (7.4) 25 (92.6) 0 (0.0) 13 (48.2) 14 (51.8) 20 (74.1) 7 (25.9) 0 (0.0)
RO 18 (72.0) 6 (24.0) 1 (4.0) 6 (24.0) 18 (72.0) 1 (4.0) 0 (0.0) 9 (36.0) 16 (64.0) 25 (100) 0 (0.0) 0 (0.0)
CDC 3 (42.9) 2 (28.6) 2 (28.6) 0 (0.0) 3 (42.9) 4 (57.1) 0 (0.0) 3 (60.0) 2 (40.0) 5 (83.3) 1 (16.7) 0 (0.0)
MLCRN-LMP 3 (60.0) 2 (40.0) 0 (0.0) 0 (0.0) 0 (0.0) 5 (100) 1 (20.0) 3 (60.0) 1 (20.0) 3 (60.0) 2 (40.0) 0 (0.0)
P value p < 0.001*   p < 0.001*   p = 0.183 p < 0.001*
  1. Abbreviations: PRMT1, protein arginine methyltransferase 1; ZEB1, Zinc Finger E-Box Binding Homeobox 1; RUNX1, Runt-related transcription factor 1; TWIST1, Twist Family BHLH Transcription Factor 1; ccRCC, clear cell renal cell carcinomas; pRCC I, papillary renal cell carcinoma type I; pRCC II, papillary renal cell carcinoma type I; chRCC, chromophobe renal cell carcinoma;CDC, collecting duct carcinomas-Bellini; MLCRN-LMP, multilocular cystic renal neoplasm of low malignant potential; +, homogenous positive; +/− heterogenous;-, homogenous negative
  2. *Statistically significant p-value