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Table 5 The comparative analysis of PRMT1, ZEB1, RUNX1 and TWIST1 immunopositivity with clinic-pathological features of the patients with ccRCC

From: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

  PRMT1 p-value ZEB1 p-value RUNX p-value TWIST1 p-value
  + + + +
Grade
 I/II 62 (68.8) 28 (31.2) 0.009* 38 (35.7) 54 (64.3) 0.093 51 (59.3) 35 (40.7) 0.846 84 (97.7) 2 (2.3) 1
 III/IV 13 (41.9) 18 (58.1) 6 (19.4) 25 (80.6) 19 (61.3) 12 (38.7) 30 (96.8) 1 (3.2)
Stage
 pT1/pT2 49 (69.0) 22 (31.0) 0.046* 23 (34.3) 44 (65.7) 0.409 37 (54.4) 31 (45.6) 0.159 67 (97.1) 2 (2.9)  
 pT3/pT4 25 (51.0) 24 (49.0) 13 (27.1) 35 (72.9) 33 (67.3) 16 (32.7) 47 (97.9) 1 (2.9) 1
Gender
 Male 44 (55.7) 35 (44.3) 0.110 23 (30.7) 52 (69.3) 0.509 46 (60.5) 30 (39.5) 0.834 76 (98.8) 1 (1.2) 0.276
 Female 29 (70.7) 12 (29.3) 14 (36.8) 24 (63.2) 24 (58.5) 17 (41.5) 39 (95.1) 2 (4.9)
Age, mean ± SD (years) 61 ± 9.45 62.6 ± 8.38 0.346 63 ± 8.75 61.2 ± 9 0.378 62 ± 8.9 61 ± 8.7 0.704 61.9 ± 8.8 59 ± 5.03 0.536
Tumour size, mean ± SD (mm) 67 ± 48.75 74.5 ± 32.3 0.362 63 ± 35.1 74.1 ± 45.7 0.181 70 ± 50 71.7 ± 32.8 0.830 70.6 ± 43.7 65 ± 18.03 0.823
  1. Abbreviations: PRMT1, protein arginine methyltransferase 1; ZEB1, Zinc Finger E-Box Binding Homeobox 1; RUNX1, Runt-related transcription factor 1; TWIST1, Twist Family BHLH Transcription Factor 1; ccRCC-clear cell renal cell carcinomas; SD, standard deviation;
  2. ISUP (International Society of Urological Pathology) nuclear grading system and updated American Joint Committee on Cancer (AJCC) tumor–node–metastasis (TNM) classification 8th edition for tumor staging were used
  3. *Statistically significant p-value