FOXM 1 induces Vasculogenic mimicry in esophageal cancer through β-catenin /Tcf4 signaling

Diagnostic Pathology

Table 1 Association of VM, FoxM1, β-catenin, TCF4 and E-cad with the clinicopathologic characteristics of ESCC patients (n = 216)

variable	VM		X²	P	Foxm1		X²	P	β-catenin (Nuclear)		X²	P	tcf4		X²	P	E cad		X²	P
variable	N	P	X²	P	N	P	X²	P	N	P	X²	P	N	P	X²	P	N	P	X²	P
Tissue
Con	216	0			183	33			177	39			180	36			38	178
ESCC	115	101			67	149			73	143			84	132			133	83
Gender			0.461	0.311			0.413	0.538			0.143	0.426			0.339	0.405			0.326	0.411
Male	67	54			35	86			42	79			43	78			73	48
Female	48	47			32	63			31	64			41	54			60	35
Age			1.334	0.166			0.112	0.440			0.204	0.396			0.302	0.365			0.331	0.409
< 60	63	58			37	84			43	78			45	76			71	50
≥ 60	52	43			30	65			30	65			39	56			62	33
Anatomical location			0.677	0.42			1.206	0.812			0.404	0.584			0.635	0.702			0.576	0.609
Upper	4	5			3	6			2	7			4	5			5	4
Middle	70	59			42	87			46	83			49	80			81	48
Lower	41	37			22	56			25	53			31	47			47	31
Gross type			0.367	0.596			3.621	0.318			3.345	0.283			3.235	0.303			2.744	0.293
Medullary	37	33			24	46			25	45			28	42			41	29
Mushroom	52	51			28	75			30	73			32	71			71	32
Ulcer type	18	15			10	23			14	19			18	15			17	16
Sclerotic type	8	2			5	5			4	6			6	4			4	6
Diameter(cm)			0.394	0.572			0.907	0.356			0.556	0.288			0.673	0.535			0.592	0.321
<5	57	51			37	71			41	67			45	63			61	47
≥ 5	58	50			30	78			32	76			39	69			72	36
Differentiation			1.714	0.315			1.384	0.301			0.706	0.41			0.811	0.532			0.863	0.501
Well	37	32			17	52			21	48			24	45			43	26
Mediate	39	32			24	47			24	46			25	46			47	24
Poor	39	37			26	50			27	49			35	41			43	33
LNM			76.885	< 0.001			75.328	< 0.001			61.215	< 0.001			65,301	< 0.001			72.325	< 0.001
Yes	14	98			5	107			6	106			5	107			106	6
No	101	3			62	42			67	37			79	25			27	77
Serosa infiltration			59.118	< 0.001			62.244	< 0.001			54.511	< 0.001			58,522	< 0.001			59.332	< 0.001
Yes	23	85			11	97			13	95			12	96			97	11
No	92	16			56	52			60	48			72	36			36	72
PTNM stage			35.319	< 0.001			46.488	< 0.001			48.027	< 0.001			47,203	< 0.001			47.623	< 0.001
I-II	67	18			63	23			63	22			55	20			21	64
III-IV	48	83			5	126			10	121			19	112			112	19

ISSN: 1746-1596