Fig. 1
From: A rare face of follicular lymphoma: reverse variant of follicular lymphoma
Case 1: a and b illustrate low-magnification and high-magnification appearances respectively (H&E stain), demonstrating lymph node architecture completely effaced by nodules with dark- staining centers and pale-staining cuffs. The dark- staining center is composed mainly of centrocytes, while the pale-staining cuff contains mainly of centroblasts. IHC staining for CD 21 shows inversely organized follicular dendritic cell (FDC) meshwork at the periphery of the nodules (c and high-power inset). The neoplastic cells were immunoreactive with CD10 (d) and negative for CD3 (e). Ki67 labelling index 40% (f)