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Table 3 Sensitivity and specificity of each criterion of Gerami and Gaiser in differentiating dysplastic nevi and early-stage acral and cutaneous melanomas

From: Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

 

Sensitivity

Specificity

Gerami’s criteria

 RREB1 > CEP6 (> 55%)

15.2%

100%

 RREB1 > 2 (> 29%)

74.6%

94.0%

 MYB<CEP6 (> 40%)

40.7%

98.0%

 CCND1 > 2 (> 38%)

91.5%

94.0%

 Totala

94.9%

94.0%

Gaiser’s criteria

 RREB1 aberrant (> 63%)

47.5%

94.0%

 MYB<CEP6 (> 31%)

50.8%

98.0%

 MYB ≥ 2.5

47.5%

94.0%

 CCND1 ≥ 2.5

88.1%

94.0%

 Totala

93.2%

90.0%

  1. a total sensitivity and specificity of the four criteria, fulfilling any of the four criteria is considered positive