IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions

Okabayshi, Misuzu; Kataoka, Tatsuki R.; Oji, Marina; Mibayashi, Satoko; Odani, Kentaro; Otsuka, Atsushi; Haga, Hironori

doi:10.1186/s13000-020-00951-x

Diagnostic Pathology

Table 1 Details of patients

From: IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions

(A) Angiosarcomas
Case	Gender	Age	Site	Lesion	Morphology	PD-L1 staining	IGF2BP3 (IMP3) staining pattern
1	F	25	Soft tissue	Metastasis	Well	Negative	Positive
2	M	61	Skin	Local recurrence	Spindle	Negative	Positive
3	F	65	Skin	Local recurrence	Epithelioid	Negative	Positive
4	M	70	Skin	Primary	Well	Positive	Positive
5	M	77	Skeletal muscle	Primary	Epithelioid	Positive	Positive
6	M	80	Skin	Local recurrence	Well	Negative	Positive
7	M	93	Skin	Local recurrence	Well	Negative	Positive
8	F	29	Soft tissue	Primary	Spindle	Negative	Positive
9	M	32	Heart	Primary	Spindle	Negative	Equivocal
10	M	42	Soft tissue	Metastasis	Spindle	Negative	Equivocal
11	F	59	Subcutis	Metastasis	Epithelioid	Positive	Equivocal
12	F	59	Skin	Primary	Spindle	Negative	Equivocal
13	F	63	Skin	Local recurrence	Spindle	Positive	Equivocal
14	F	64	Breast	Primary	Epithelioid	Negative	Equivocal
15	M	66	Skin	Local recurrence	Well	Negative	Equivocal
16	M	70	Skin	Primary	Well	Negative	Equivocal
17	M	70	Skin	Primary	Spindle	Negative	Equivocal
18	M	73	Subcutis	Primary	Well	Positive	Equivocal
19	M	75	Skin	Primary	Well	Positive	Equivocal
20	F	77	Soft tissue	Primary	Spindle	Negative	Equivocal
21	M	82	Skin	Primary	Well	Negative	Equivocal
22	M	83	Skin	Local recurrence	Well	Negative	Equivocal
23	F	84	Skin	Local recurrence	Epithelioid	Positive	Equivocal
24	F	87	Skin	Primary	Well	Negative	Equivocal
25	M	88	Skin	Primary	Well	Negative	Equivocal
26	F	65	Skin	Primary	Well	Negative	Negative
27	M	75	Kidney	Primary	Spindle	Negative	Negative
28	M	78	Skin	Local recurrence	Well	Negative	Negative
29	M	86	Skin	Primary	Well	Positive	Negative
30	F	87	Skin	Primary	Spindle	Negative	Negative
(B) Epithelioid hemangioendotheliomas
Case	Gender	Age	Site	IGF2BP3 (IMP3) staining pattern
1	M	23	Cerebrum	Positive
2	M	81	Soft tissue	Positive
3	M	27	Bone	Equivocal
4	M	65	Esophagus	Equivocal
5	F	33	Liver	Negative
(C) Hemangiomas
Case	Gender	Age	Site	IGF2BP3 (IMP3) staining pattern
1	F	42	Lung	Negative
2	F	45	Skin	Negative
3	M	58	Skin	Negative
4	F	64	Skin	Negative
5	M	69	Skin	Negative
6	F	69	Soft tissue	Negative
7	F	80	Soft tissue	Negative
8	M	80	Tongue	Negative
9	M	82	Skin	Negative
10	M	85	Skin	Negative
(D) Pyogenic granuloma
Case	Gender	Age	Site	IGF2BP3 (IMP3) staining pattern
1	F	30	Lip	Equivocal
2	F	63	Skin	Equivocal
3	M	65	Nasal cavity	Equivocal
4	M	65	Skin	Equivocal
5	M	65	Skin	Equivocal
6	M	78	Tongue	Equivocal
7	M	33	Skin	Negative
8	F	42	Soft tissue	Negative
9	M	48	Skin	Negative
10	M	66	Skin	Negative
11	M	66	Skin	Negative
12	M	67	Skin	Negative
13	M	75	Tongue	Negative
14	M	78	Skin	Negative
(E) Granulation tissue
Case	Gender	Age	Site	IGF2BP3 (IMP3) staining pattern
1	F	34	Skin	Negative
2	F	41	Skin	Negative
3	F	46	Skin	Negative
4	F	51	Skin	Negative
5	M	57	Skin	Negative
6	M	60	Skin	Negative
7	F	68	Soft tissue	Negative
8	M	74	Subcutis	Negative
9	M	75	Buccal mucosa	Negative
10	F	80	Skin	Negative
11	F	82	Lip	Negative
12	M	86	Mandible	Negative

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ISSN: 1746-1596

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