Fig. 1

Ovarian well-differentiated mucinous adenocarcinoma with mural nodules of anaplastic carcinoma (patient 1). Well differentiated mucinous carcinoma has an expansile [a] and destructive [b] invasive pattern. Depicted in c & d are the mural nodules of anaplastic carcinoma that are composed of spindled cells and polygonal cells with marked nuclear pleomorphism and active mitotic figure. [d, arrow]. The presence of atypical glands [right lower in C] is indicative of the transitional zones of the mural nodules. Lymphovascular invasion is shown in E [arrow]. The tumor cells in the mural nodules have a strong CK [F], an aberrant p53 expression [G], and a high Ki67 index [H]. (H&E: A-C × 100, D × 400, E × 200; immunohistochemistry, F-H × 200)