Table 2 Immunohistochemical and molecular findings of ovarian mucinous tumors with mural nodules
From: Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases
Patient 1 | Patient 2 | Patient 3 | ||||
|---|---|---|---|---|---|---|
Mucinous tumor | Mural nodule | Mucinous tumor | Mural nodule | Mucinous tumor | Mural nodule | |
Pathological diagnosis | WDMAC | Anaplastic carcinoma | MBT, focal AC | Sarcoma | MBT, focal WDMAC | SLMN |
Immunostaining | ||||||
CK, CK7 | +++ | ++ ~ +++ | +++ | – | +++ | +/− |
EMA, CK20, CEA, CDX2 | + | – | + | – | + | – |
PAX8, ER, PR | – | – | – | – | – | – |
CD10 | – | – | – | +++ | – | + |
SMA | – | – | – | – | – | + |
P53 | WT | MT | WT | WT | WT | WT |
Ki67 index | 40% | 80% | 30% | 80% | 40% | 50% |
Hotspot mutations | ||||||
KRAS(G12V, G12A, G12D, G13D) | G12A | G12A | – | – | – | – |
HRAS (Q61H) | – | – | – | – | – | – |
AKT1 (E17K) | – | – | – | – | – | – |
PI3KCA (E542K, E545K, E546K) | – | – | – | – | – | – |