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Table 2 Immunohistochemical and molecular findings of ovarian mucinous tumors with mural nodules

From: Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases

 Patient 1Patient 2Patient 3
Mucinous tumorMural noduleMucinous tumorMural noduleMucinous tumorMural nodule
Pathological diagnosisWDMACAnaplastic carcinomaMBT, focal ACSarcomaMBT, focal WDMACSLMN
Immunostaining
 CK, CK7+++++ ~ ++++++++++/−
 EMA, CK20, CEA, CDX2+++
 PAX8, ER, PR
 CD10++++
 SMA+
 P53WTMTWTWTWTWT
 Ki67 index40%80%30%80%40%50%
Hotspot mutations
KRAS(G12V, G12A, G12D, G13D)G12AG12A
HRAS (Q61H)
AKT1 (E17K)
PI3KCA (E542K, E545K, E546K)
  1. Abbreviations: AC adenocarcinoma, MBT mucinous borderline tumor, MT mutant-type, SLMN sarcoma-like mural nodules, WDMAC well differentiated mucinous adenocarcinoma, WT wild-type