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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Density and size of lymphoid follicles are useful clues in differentiating primary intestinal follicular lymphoma from intestinal reactive lymphoid hyperplasia

Fig. 2

A representative case of a low-grade primary intestinal follicular lymphoma (Case No. 4, except Panel h, i and j). a Low-power view shows a large lymphoid follicle in the lamina propria of duodenal mucosa (H&E stain, × 40). The mantle zone indicated by black arrowheads is attenuated. In this case, the mucosa is intact, without erosion or ulceration. b The follicle is composed mainly of small- to medium-sized centrocytes without tingible body macrophages (× 400). Immunohistochemistry shows that the neoplastic cells express CD10 (c, × 40), CD20 (d, × 40), BCL-2 (e, × 40), and BCL-6 (f, × 40). The follicular dendritic meshworks of this case show a characteristic duodenal pattern by immunostaining with CD23 (g, × 40), in contrast to the nodal pattern in Case no. 11 (h, × 40). FISH assay using Vysis IGH/BCL2 Dual Color, Dual Fusion Translocation Probe (IGH in SpectrumGreen and BCL2 in SpectrumOrange). i A normal cell showing two orange and two green signals (2O2G), indicating no translocation of either IGH or BCL2 genes. j A neoplastic cell with reciprocal IGH/BCL2 translocation showing one orange, one green (representing the normal homolog) and one fused (orange/green) signal in yellow (1O1G1F; i and j from Case no. 21)

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Diagnostic Pathology

ISSN: 1746-1596

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