miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2

Table 1 Association between miR-541 expression and clinical features in OS patients

Parameters	Cases No. (n = 106)	miR-541-low (n = 62)	miR-541-high (n = 44)	P value
Gender
Male	64	38	26	0.861
Female	42	24	18	0.861
Age
< 18	60	32	28	0.970
≥ 18	46	30	16	0.970
Anatomical location
Tibia/femur	66	37	29	0.808
Fibula	24	15	9	0.808
Humerus	16	10	6
Tumor size (cm)
< 8	55	26	29	0.015
≥ 8	51	36	15	0.015
Enneking stage
I-IIB	41	20	21	0.005
IIB-III	65	42	23	0.005
Distant metatasis
Negative	50	22	28	0.004
Positive	56	40	16	0.004
Histological subtype
Osteoblastic	62	35	27	0.501
Chondroblastic	24	13	11
Fibroblastic	20	14	6
Histological gradeTumor differentiation
Well/moderate	61	29	32	0.008
Poor	45	33	12	0.008

ISSN: 1746-1596