Fig. 5
From: Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors
Trk immunohistochemistry shows a Nuclear positivity in TPR-NTRK1 fusion sarcoma (Case 1), b mostly nuclear membrane, and cytoplasmic stain in LMNA-NTRK1 fusion sarcoma (Case 2). and c mainly cytoplasmic stain in ETV6-NTRK3 fusion sarcoma. In Fig. b, the Trk-negative cells are infiltrating inflammatory cells (a-c: Trk IHC, lower bar: 50 μm). d. locus-specific identifier (LSI) FISH study using ETV6 fluorescence dual-color break apart DNA probes show one fused and one widely separated SpectrumGreen and SpectrumOrange signals in an infantile fibrosarcoma with ETV6-NTRK3 fusion-positive