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Table 3 Immunohistochemical results of published CIRC tumors

From: Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

Author(s) Primary/Relapse CAM5.2 (CK8) CK18 AE1/AE3 EMA Vimentin Desmin α-SMA S-100 CD21 CD68 p53
Gould et al. [8]   + + + + + + ND ND ND
Gould et al. [8]   + + + + + + + ND ND ND
Gould et al. [8]   + + + + + + ND ND ND
Chan et al. [9]   + + + +/− + ND
Chan et al. [9]   + + + + + ND
Chan et al. [9]   + + + +/− + ND
Schuerfeld et al. [10]   + + + + + ND + + ND
Lucioni et al. [11] *primary ND + + + 20%
relapse + ND +/− + > 60%
Karim et al. [12]   ND ND + ND ND + + ND ND
Goto et al. [13]   + ND + +/− ND +/− +/− ND
Bösmüller et al. [14]   + ND + + + +/−
Current case primary + + + + + 95%
relapse + + + + + 80%
  1. - negative, +/− often/partially positive, + positive, * primary tumor was diagnosed as fibroblastic reticulum cell tumor; ND Not done