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Table 3 Immunohistochemical results of published CIRC tumors

From: Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

Author(s)

Primary/Relapse

CAM5.2 (CK8)

CK18

AE1/AE3

EMA

Vimentin

Desmin

α-SMA

S-100

CD21

CD68

p53

Gould et al. [8]

 

+

+

+

+

+

+

ND

ND

ND

Gould et al. [8]

 

+

+

+

+

+

+

+

ND

ND

ND

Gould et al. [8]

 

+

+

+

+

+

+

ND

ND

ND

Chan et al. [9]

 

+

+

+

+/−

+

ND

Chan et al. [9]

 

+

+

+

+

+

ND

Chan et al. [9]

 

+

+

+

+/−

+

ND

Schuerfeld et al. [10]

 

+

+

+

+

+

ND

+

+

ND

Lucioni et al. [11]

*primary

ND

+

+

+

20%

relapse

+

ND

+/−

+

> 60%

Karim et al. [12]

 

ND

ND

+

ND

ND

+

+

ND

ND

Goto et al. [13]

 

+

ND

+

+/−

ND

+/−

+/−

ND

Bösmüller et al. [14]

 

+

ND

+

+

+

+/−

Current case

primary

+

+

+

+

+

95%

relapse

+

+

+

+

+

80%

  1. - negative, +/− often/partially positive, + positive, * primary tumor was diagnosed as fibroblastic reticulum cell tumor; ND Not done