Table 3 Summary information of 7 cases of pilomatrical carcinosarcoma
From: Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review
Hanly et al., 1994 [7] | Scholl et al., 2010 [4] | Clark et al., 2017 [2] | Suyama et al., 2017 [5] | Leecy et al., 2018 [3] | Mori et al., 2019 [6] | Present case | |
|---|---|---|---|---|---|---|---|
Age | 36 | 23 | 77 | 73 | 87 | 100 | 74 |
Sex | Male | Male | Male | Male | Female | Female | Female |
Quiescent period | > 24 months | 6 months | 4 years | Several decades | 10 years | ||
Ulcer | + | – | – | – | – | – | |
Size (cm) | 4 | 5 | 2 | 1.6 | 1.5 | 2.5 | |
Site | Cheek | Periauricular | Cheek | Cheek | Hand | Temple | Scalp |
Epithelial component | Benign pilomatrixoma | Benign pilomatrixoma | Pilomatrical a component +BCC | Malignant pilomatricoma | Malignant pilomatricoma | Malignant pilomatricoma | Malignant pilomatricoma + SCC |
Mesenchymal component | Undifferentiated pleomorphic sarcoma | Spindle cell sarcoma | Undifferentiated pleomorphic sarcoma | Spindle cell sarcoma | Undifferentiated pleomorphic sarcoma | Spindle cell sarcoma | Undifferentiated pleomorphic sarcoma |
β-catenin IHC | Abnormal type in basaloid cells in the epithelial component | Normal type in basaloid cells in the epithelial component | Abnormal type in both component | Abnormal type In both component | |||
CTNNB1 sequencing | Exon 3 wild type | Exon 3, 4, 5 wild type | |||||
Chromosomal abnormality | – | – | – | – | CGH: Homozygous deletion of chr 17q25, 9p21; 9p24.1-p13.2 and 20p13-p11.1 gain in both components | – | FISH: varying gains of copy number of 9p21, Chr 3, 7, 17 in both component |