Table 6 Univariate and multivariate Cox regression analyses of potential prognostic factor for progression- free survival (PFS) in patients with colorectal cancer

Nuclear TWIST1 expression High versus Low

1.9 (1.0–3.6)

0.049

1.62 (0.84–3.13)

0.149

Tumor differentiation

<  0.001

<  0.001

Moderate versus well

2.5 (1.3–4.7)

0.005

2.2 (1.1–4.3)

0.013

Poor versus well

6.3 (2.6–15.0)

<  0.001

5.4 (2.2–13.3)

<  0.001

Neural invasion (NI)

0.3 (0.1–0.5)

<  0.001

–

–

Lymph node invasion (LNI)

0.5 (0.3–0.9)

0.038

–

–

Distant metastasis

0.1 (0.0–0.3)

<  0.001

–

–

Tumor recurrence

0.1 (0.0–0.2)

<  0.001

–

–