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Table 6 Univariate and multivariate Cox regression analyses of potential prognostic factor for progression- free survival (PFS) in patients with colorectal cancer

From: Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Covariate Univariate analysis Multivariate analysis
HR (95% CI) P-value HR (95% CI) P-value
Nuclear TWIST1 expression High versus Low 1.9 (1.0–3.6) 0.049 1.62 (0.84–3.13) 0.149
Tumor differentiation   <  0.001   <  0.001
Moderate versus well 2.5 (1.3–4.7) 0.005 2.2 (1.1–4.3) 0.013
Poor versus well 6.3 (2.6–15.0) <  0.001 5.4 (2.2–13.3) <  0.001
Neural invasion (NI) 0.3 (0.1–0.5) <  0.001
Lymph node invasion (LNI) 0.5 (0.3–0.9) 0.038
Distant metastasis 0.1 (0.0–0.3) <  0.001
Tumor recurrence 0.1 (0.0–0.2) <  0.001
  1. H-score indicates histological score
  2. Values in bold are statistically significant
  3. The variables with P value less than 0.05 were included in multivariable analyses
  4. hazard ratio, CI confidence interval