Fig. 5

Oncoplot reporting the most recurrently mutated genes across the d-MMR GC samples analyzed in this study. TMB, MSI status, gene mutation frequency and mutation type were detected by next generation sequencing. In high-TMB and MSI tumors, the deletion mutation of certain genes (such as RNF43, BCORL1 and ATR) is apparent. d-MMR, mismatch repair-deficient; GC, gastric cancer; TMB, tumor mutation burden; MSI, microsatellite instability